1. Design and synthesis of new benzylidene-quinazolinone hybrids as potential anti-diabetic agents: In vitro α-glucosidase inhibition, and docking studies.
- Author
-
Khalifa, Mohamed M., Sakr, Helmy M., Ibrahim, Albaraa, Mansour, Ahmed M., and Ayyad, Rezk R.
- Subjects
- *
MOLECULAR docking , *ALPHA-glucosidases , *GLUCOSIDASES , *MOLECULAR interactions , *HYDROCORTISONE , *BLOOD sugar , *RATS - Abstract
• Sixteen compounds of novel benzylidene-quinazolinone hybrids derivatives were designed and synthesized. • The target compounds were tested in vivo for their anti-hyperglycemic effects against STZ-induced hyperglycemic rats. • In vitro α-glucosidase inhibitory activity was evaluated. • A homology model of α-glucosidase was built. • Molecular docking studies were carried out. A novel series of benzylidene-quinazolinone hybrids 8 a,b and 10 a-n were designed, synthesized, and evaluated for their in vitro α -glucosidase inhibitory effect aiming to discover efficient anti-diabetic agents. The synthesized compounds were assessed for their in vivo anti-hyperglycemic activities against STZ-induced hyperglycemic rats. Five compounds (10 m , 10 f , 10 c , 10 d and 8 b) demonstrated potent activities with percent reduction in blood glucose levels of 43.07, 40.14, 39.83, 37.04 and 36.16, respectively. The most active members were further evaluated in vitro for their α -glucosidase inhibitory binding affinities. Among them, Compound 10 m containing 4-hydroxybenzylidene moiety and compound 10 f with 4-chlorobenzylidene moiety connected to the acetohydrazide demonstrated the most potent inhibitory activities towards α -glucosidase with IC 50 values of 561 and 610 µM, respectively. Molecular docking study was performed in order to understand the molecular interactions between the molecule and enzyme. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF