1. hPSC-derived organoids: models of human development and disease
- Author
-
Jason R. Spence and Tristan Frum
- Subjects
0301 basic medicine ,Cell signaling ,Intestinal organoids ,Disease ,Computational biology ,Review ,Stem cells ,Biology ,Development ,Organoids ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Disease modeling ,Drug Discovery ,Human development (biology) ,Organoid ,Molecular Medicine ,Stem cell ,Induced pluripotent stem cell ,030217 neurology & neurosurgery ,Genetics (clinical) ,Human - Abstract
Organoids derived from human pluripotent stem cells (hPSCs) have emerged as important models for investigating human-specific aspects of development and disease. Here we discuss hPSC-derived organoids through the lens of development—highlighting how stages of human development align with the development of hPSC-derived organoids in the tissue culture dish. Using hPSC-derived lung and intestinal organoids as examples, we discuss the value and application of such systems for understanding human biology, as well as strategies for enhancing organoid complexity and maturity.
- Published
- 2020