1. Early reduction of SARS-CoV-2-replication in bronchial epithelium by kinin B
- Author
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Constanze A, Jakwerth, Martin, Feuerherd, Ferdinand M, Guerth, Madlen, Oelsner, Linda, Schellhammer, Johanna, Giglberger, Lisa, Pechtold, Claudia, Jerin, Luisa, Kugler, Carolin, Mogler, Bernhard, Haller, Anna, Erb, Barbara, Wollenberg, Christoph D, Spinner, Thorsten, Buch, Ulrike, Protzer, Carsten B, Schmidt-Weber, Ulrich M, Zissler, and Adam M, Chaker
- Subjects
Mice ,Receptor, Bradykinin B2 ,SARS-CoV-2 ,Animals ,Humans ,RNA, Viral ,Epithelium ,COVID-19 Drug Treatment - Abstract
SARS-CoV-2 has evolved to enter the host via the ACE2 receptor which is part of the kinin-kallikrein pathway. This complex pathway is only poorly understood in context of immune regulation but critical to control infection. This study examines SARS-CoV-2-infection and epithelial mechanisms of the kinin-kallikrein-system at the kinin B
- Published
- 2021