1. Inhibition of the kinetics of chelation of nickel (II) with malonate ion by β-cyclodextrin
- Author
-
S. Petrucci and Warren M. Hirsch
- Subjects
chemistry.chemical_classification ,Aqueous solution ,Cyclodextrin ,Kinetics ,Inorganic chemistry ,chemistry.chemical_element ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,carbohydrates (lipids) ,Nickel ,chemistry.chemical_compound ,Malonate ,Non-competitive inhibition ,chemistry ,Stability constants of complexes ,polycyclic compounds ,Materials Chemistry ,lipids (amino acids, peptides, and proteins) ,Chelation ,Physical and Theoretical Chemistry ,Spectroscopy - Abstract
Relaxation times, determined by the pressure-jump technique, for the kinetics of chelation of nickel (II) by malonate ion are significantly prolonged by the addition of β-cyclodextrin to aqueous solutions. The effect is due to inclusion of the malonate into the β-cyclodextrin cavity. In fact addition of glucose in a 7:1 ratio to malonate ion does not affect the kinetics of complexation with Ni 2+ . The effect is also specific to the size of the ring since α-cyclodextrin and γ-cyclodextrin do not show any effect on the above relaxation times. The kinetic data are interpreted to indicate a competitive inhibition process. β-cyclodextrin is bound to the anion and prevents its chelation reaction with Ni 2+ . The mechanism treats the data quantitatively with an inclusion formation constant between malonate and β-cyclodextrin of the order of 10 2 M −1 .
- Published
- 1984
- Full Text
- View/download PDF