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The pattern recognition receptors RIG-I-like receptors (RLRs) are critical molecules for cytosolic viral recognition and for subsequent activation of type I interferon production. The interferon signaling pathway plays a key role in viral detection and generating antiviral responses. Among the many pathogens, the non-segmented negative sense RNA viruses target the RLR pathway using a variety of mechanisms. Here, I review the current state of knowledge on the molecular mechanisms that allow non-segmented negative sense RNA virus recognition and antagonism of RLRs. Unlabelled Image • Type I IFN signaling is important for pathogen recognition and activation of antiviral responses. • RIG-I-like receptors are highly regulated cytosolic pattern recognition receptors that stimulate IFN signaling. • Non-segmented negative strand RNA viruses have developed different strategies and multipronged approaches to inhibit RLR signaling. [ABSTRACT FROM AUTHOR]