1. Emerging Insights into Noncanonical Inflammasome Recognition of Microbes.
- Author
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Russo, Ashley J., Behl, Bharat, Banerjee, Ishita, and Rathinam, Vijay A.K.
- Subjects
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INFLAMMASOMES , *MICROBIAL metabolism , *IMMUNE recognition , *LIPOPOLYSACCHARIDES , *GRAM-negative bacteria , *MOLECULAR biology , *CYTOKINES - Abstract
Inflammasomes are cytosolic multi-molecular complexes that sense intracellular microbial danger signals and metabolic perturbations. Inflammasome activation leads to the activation of caspase-1 and the release of pro-inflammatory cytokines IL-1β and IL-18 accompanied by cell death. An inflammasome-based surveillance machinery for Gram-negative bacterial infections has been recently discovered. This noncanonical inflammasome relies on sensing the cytosolic presence of lipopolysaccharide of Gram-negative bacteria via inflammatory caspases such as caspase-4, -5, and -11. This review discusses the recent findings related to the mechanism of activation of the noncanonical inflammasome and its biological functions. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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