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Objective To develop ShanHu granules through clinical prescription for the treatment of tumors, in order to lay the foundation for further development of new drug. Methods The paclitaxel, total saponins and total polysaccharides in the compounds were extracted by different solvents,and the extracts were mixed into powder. In order to preparation ShanHu granules, the powder was made into thick paste with concentration of 1.30 g/mL by adding water, then 1.2 times ingredients (equal mixture of soluble starch and dextrin) and 2.00% stevioside were added with 85.00% ethanol as wetting agents. Results The applied ingredients were inexpensive with simple preparation process and low cost of production,which was beneficial to socialized mass production,and the developed granules were easy to absorb and rapid. Conclusion Although the extraction process is complex,it can extract the active ingredients from the compounds as much as possible. [ABSTRACT FROM AUTHOR]