1. Emergence of macrolide-resistant Streptococcus pyogenes emm12 in southern Taiwan from 2000 to 2019
- Author
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Chia Yu Chi, Ching Chuan Liu, Ching Fen Shen, Pei Jane Tsai, Jiunn Jong Wu, Wei Chun Tsai, Fan Ching Shen, Ya Lan Lin, Yee Shin Lin, and Shuying Wang
- Subjects
Male ,0301 basic medicine ,Microbiology (medical) ,medicine.medical_specialty ,Antibiotic resistance ,Streptococcus pyogenes ,030106 microbiology ,Population ,Taiwan ,Erythromycin ,Azithromycin ,emm12 ,Microbiology ,03 medical and health sciences ,0302 clinical medicine ,Bacterial Proteins ,Risk Factors ,Streptococcal Infections ,Internal medicine ,Drug Resistance, Bacterial ,Epidemiology ,Prevalence ,medicine ,Humans ,Immunology and Allergy ,030212 general & internal medicine ,Child ,education ,Respiratory Tract Infections ,Retrospective Studies ,education.field_of_study ,General Immunology and Microbiology ,Molecular epidemiology ,business.industry ,General Medicine ,medicine.disease ,QR1-502 ,Anti-Bacterial Agents ,Infectious Diseases ,Upper respiratory tract infection ,Child, Preschool ,Scarlet fever ,Female ,Macrolides ,business ,medicine.drug - Abstract
Background: Group A Streptococcus (GAS) is an important pathogen causing morbidity and mortality worldwide. Surveillance of resistance and emm type has important implication to provide helpful information on the changing GAS epidemiology and empirical treatment. Methods: To study the emergence of resistant GAS in children with upper respiratory tract infection (URTI), a retrospective study was conducted from 2000 to 2019 in southern Taiwan. Microbiological studies, including antibiotic susceptibility, were performed. GAS emm types and sequences were determined by molecular methods. The population was divided into two separate decades to analyze potential changes over time. The 1st decade was 2000–2009; the 2nd decade was 2010–2019. Multivariate analyses were performed to identify independent risk factors associated with macrolide resistance between these periods. Results: A total of 320 GAS from 339 children were enrolled. Most of the children (75%) were under 9 years of age. The most common diagnosis was scarlet fever (225, 66.4%), and the frequency increased from 54.8% in the 1st to 77.9% in the 2nd decade (p
- Published
- 2021