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The aim of this work is to valorise the species Ammodaucus leucotrichus Coss which is known by its abundance in perillaldehyde. The plant material was collected from two regions in Morocco: Errachidia and Smara region, then was hydrodistilled. The essential oils (EOs) obtained were firstly characterized by gas chromatography coupled to mass spectrometry (GC-MS). Secondly the EO with the major component is the perillaldehyde was used as starting material to semi-synthesize three p-menthane monoterpenoids. The semi-synthesized compounds from perillaldehyde were studied for their docking behavior against Lung Cancer with the crystallographic structure of the kinase domain of EGFR protein using surflex-docking. The GC/MS analysis of essential oils, showed a total of 25 components accounts 99.51% for Errachidia's EO while 28 components account for 99.83% for Smara's EO. GC/MS analysis showed that perillaldehyde is the major components in the EO of Errachidia with a percentage of 74.71%. For this purpose, Errachidia's EO was used to semi-synthesize the perilla alcohol, the perillic acid, and the perillartine. The three compounds were obtained in good yield, their structures were confirmed by GC/MS and Infrared (IR). The molecular docking study showed a good binding affinity between the perilla alcohol (POH) and the lung cancer receptor than perillic acid and perillartine. The species Ammodaucus leucotrichus Coss. could be considered a promising source of p-menthan monoterpenoids, known for their anticancerous properties. [ABSTRACT FROM AUTHOR]

In order to develop a strategy for the safe management of insect pests in stored agricultural commodities, the essential oil of Artemisia herba alba Asso. was tested against Callosobruchus maculatus Fabricius raised on seeds of Cicer arietinum (L.) at 20-30°C and 65±5% relative humidity under storage conditions. Chickpea seeds were fumigated with concentrations of essential oil and then infested by young adults of bruchids. On each treated or control lot, 10 newly emerged pairs were released. The number of dead bruchids and number of eggs hatched and unhatched from the seeds were counted. At the end of their development, adults emerged from treated and untreated seeds were counted separately by sex and the success rate was calculated. Three replicates were conducted for each treatment. The essential oil extracted from Artemisia herba alba Asso was analyzed by gas chromatography coupled with mass spectrometry (GC/MS). The chromatogram of the essential oil of Artemisia herba alba Asso shows 15 signals relating to the 15 compounds of which camphor is the major constituent with a percentage of 96.15%. The results of the biological tests obtained showed that the essential oil of Artemisia herba alba Asso exerts repellent and toxic effects on Callosobruchus maculatus. It causes a high mortality of adults and affects its fertility, fertility, and success rate in a very significant way compared to controls. These show that fumigation of stored commodities with the essential oil of Artemisia herba alba Asso against insect pests can be considered under storage conditions without risk to consumers and the environment. [ABSTRACT FROM AUTHOR]

The aim of this work is to determine the chemical composition of the essential oil of Origanum compactum, from the region of Meknes (Morocco), and their antimicrobial effect, and on the other hand, to carry out a comparison between the chemical composition of this essential oil with the six regions of Morocco: Larache, Chefchaouen, Al Hoceïma, Tetouan, Taounate and Rabat. The essential oils of Origanum compactum thus obtained were analyzed and identified by gas chromatography coupled with mass spectrometry (GC/MS). To determine the similarities and dissimilarities between the chemical compositions of the essential oil of Origanum compactum from the Meknes region with the other six regions of Morocco, we performed the principal component analysis (ACP). Regarding antimicrobial activity, the essential oils of Origanum compactum have shown significant inhibitory activity against the bacteria and molds studied. [ABSTRACT FROM AUTHOR]