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The permeate flux ( J ) and volume throughput ( Q ) dependence on rotation ( ω ), diameter ( D ), Reynolds Number (Re) and shear rate ( γ ) for a high shear rotary membrane system (HSR-MS) was investigated to determine if larger, slower rotated discs could lead to a smaller system weight and foot/cube-print which is needed for US Navy shipboard placement. The HSR-MS steady state flux ( J ss ) was highly dependent on ω and D ranging from 10 to 433 L/m 2 hr (LMH). For every 100 rpm increase in ω , J ss increased on average by 26 LMH. The outer membrane third provided ≥50% of the total flow, with the inner third providing about 15%. The J ss – γ relationship was extended to larger membranes (312 and 374 mm) and predicted that J ss increased by about 15% for each increase in size. Q ss was much more sensitive to increases in diameter and corresponding surface area – Q increased by 45% for D =267 mm→312 mm and 65% increased for D =312 mm→374 mm (≈1% increase in Q per mm increase in diameter). Collectively, the results show that larger discs, rotated at lower rotations, can produce similar or greater Q compared to smaller discs rotating faster.