Search

Your search keyword '"Passeri, Daniela"' showing total 5 results
Start Over Author "Passeri, Daniela" Journal journal of medicinal chemistry
5 results on '"Passeri, Daniela"'

2. First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53

Author

Nowak, Radosław P., primary, Tumber, Anthony, additional, Hendrix, Eline, additional, Ansari, Mohammad Salik Zeya, additional, Sabatino, Manuela, additional, Antonini, Lorenzo, additional, Andrijes, Regina, additional, Salah, Eidarus, additional, Mautone, Nicola, additional, Pellegrini, Francesca Romana, additional, Simelis, Klemensas, additional, Kawamura, Akane, additional, Johansson, Catrine, additional, Passeri, Daniela, additional, Pellicciari, Roberto, additional, Ciogli, Alessia, additional, Del Bufalo, Donatella, additional, Ragno, Rino, additional, Coleman, Mathew L., additional, Trisciuoglio, Daniela, additional, Mai, Antonello, additional, Oppermann, Udo, additional, Schofield, Christopher J., additional, and Rotili, Dante, additional

Published
2021
Full Text
View/download PDF

3. Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure–Activity Relationship, X-ray Crystal Structure, and Anticancer Activity

Author

Moniot, Sébastien, primary, Forgione, Mariantonietta, additional, Lucidi, Alessia, additional, Hailu, Gebremedhin S., additional, Nebbioso, Angela, additional, Carafa, Vincenzo, additional, Baratta, Francesca, additional, Altucci, Lucia, additional, Giacché, Nicola, additional, Passeri, Daniela, additional, Pellicciari, Roberto, additional, Mai, Antonello, additional, Steegborn, Clemens, additional, and Rotili, Dante, additional

Published
2017
Full Text
View/download PDF

4. Discovery of 3α,7α,11β-Trihydroxy-6α-ethyl-5β-cholan-24-oic Acid (TC-100), a Novel Bile Acid as Potent and Highly Selective FXR Agonist for Enterohepatic Disorders

Author

Pellicciari, Roberto, primary, Passeri, Daniela, additional, De Franco, Francesca, additional, Mostarda, Serena, additional, Filipponi, Paolo, additional, Colliva, Carolina, additional, Gadaleta, Raffaella Maria, additional, Franco, Placido, additional, Carotti, Andrea, additional, Macchiarulo, Antonio, additional, Roda, Aldo, additional, Moschetta, Antonio, additional, and Gioiello, Antimo, additional

Published
2016
Full Text
View/download PDF

5. Discovery and Structure-Activity Relationships of Novel ss DAF-12 Receptor Modulators.

Author

Ceccarelli G, Goracci L, Carotti A, Paccoia F, Passeri D, Cipolloni M, Di Bona S, Cruciani G, Pellicciari R, and Gioiello A

Subjects
Animals, Humans, Steroids therapeutic use, Life Cycle Stages, Structure-Activity Relationship, Strongyloidiasis drug therapy, Strongyloidiasis parasitology, Strongyloides stercoralis metabolism
Abstract

The nuclear receptor ss DAF-12 has been recognized as the key molecular player regulating the life cycle of the nematode parasite Strongyloides stercoralis . ss DAF-12 ligands permit the receptor to function as an on/off switch modulating infection, making it vulnerable to therapeutic intervention. In this study, we report the design and synthesis of a set of novel dafachronic acid derivatives, which were used to outline the first structure-activity relationship targeting the ss DAF-12 receptor and to unveil hidden properties shared by the molecular shape of steroidal ligands that are relevant to the receptor binding and modulation. Moreover, biological results led to the discovery of sulfonamide 3 as a submicromolar ss DAF-12 agonist endowed with a high receptor selectivity, no toxicity, and improved properties, as well as to the identification of unprecedented ss DAF-12 antagonists that can be exploited in the search for novel chemical tools and alternative therapeutic approaches for treating parasitism such as Strongyloidiasis.

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results