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Your search keyword '"Missert, Joseph R."' showing total 13 results
Start Over Author "Missert, Joseph R." Journal journal of medicinal chemistry
13 results on '"Missert, Joseph R."'

1. Tumor-Avid 3-(1′-Hexyloxy)ethyl-3-devinylpyrpyropheophorbide-a (HPPH)-3Gd(III)tetraxetan (DOTA) Conjugate Defines Primary Tumors and Metastases

Author

Cheruku, Ravindra R., primary, Turowski, Steven G., additional, Durrani, Farukh A., additional, Tabaczynski, Walter A., additional, Cacaccio, Joseph, additional, Missert, Joseph R., additional, Curtin, Leslie, additional, Sexton, Sandra, additional, Alberico, Ronald, additional, Hendler, Craig M., additional, Spernyak, Joseph A., additional, Grossman, Zachary, additional, and Pandey, Ravindra K., additional

Published
2022
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3. Synthesis, Tumor Specificity, and Photosensitizing Efficacy of Erlotinib-Conjugated Chlorins and Bacteriochlorins: Identification of a Highly Effective Candidate for Photodynamic Therapy of Cancer

Author

Cheruku, Ravindra R., primary, Cacaccio, Joseph, additional, Durrani, Farukh A., additional, Tabaczynski, Walter A., additional, Watson, Ramona, additional, Siters, Kevin, additional, Missert, Joseph R., additional, Tracy, Erin C., additional, Dukh, Mykhaylo, additional, Guru, Khurshid, additional, Koya, Richard C., additional, Kalinski, Pawel, additional, Baumann, Heinz, additional, and Pandey, Ravindra K., additional

Published
2021
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4. Epidermal Growth Factor Receptor-Targeted Multifunctional Photosensitizers for Bladder Cancer Imaging and Photodynamic Therapy

Author

Cheruku, Ravindra R., primary, Cacaccio, Joseph, additional, Durrani, Farukh A., additional, Tabaczynski, Walter A., additional, Watson, Ramona, additional, Marko, Aimee, additional, Kumar, Rahul, additional, El-Khouly, Mohamed E., additional, Fukuzumi, Shunichi, additional, Missert, Joseph R., additional, Yao, Rutao, additional, Sajjad, Munawwar, additional, Chandra, Dhyan, additional, Guru, Khurshid, additional, and Pandey, Ravindra K., additional

Published
2019
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5. Highly Effective Dual-Function Near-Infrared (NIR) Photosensitizer for Fluorescence Imaging and Photodynamic Therapy (PDT) of Cancer

Author

Patel, Nayan, primary, Pera, Paula, additional, Joshi, Penny, additional, Dukh, Mykhaylo, additional, Tabaczynski, Walter A., additional, Siters, Kevin E., additional, Kryman, Mark, additional, Cheruku, Ravindra R., additional, Durrani, Farukh, additional, Missert, Joseph R., additional, Watson, Ramona, additional, Ohulchanskyy, Tymish Y., additional, Tracy, Erin C., additional, Baumann, Heinz, additional, and Pandey, Ravindra K., additional

Published
2016
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6. In Vitro Cellular Uptake and Dimerization of Signal Transducer and Activator of Transcription-3 (STAT3) Identify the Photosensitizing and Imaging-Potential of Isomeric Photosensitizers Derived from Chlorophyll-a and Bacteriochlorophyll-a

Author

Srivatsan, Avinash, primary, Wang, Yanfang, additional, Joshi, Penny, additional, Sajjad, Munawwar, additional, Chen, Yihui, additional, Liu, Chao, additional, Thankppan, Krishnakumar, additional, Missert, Joseph R., additional, Tracy, Erin, additional, Morgan, Janet, additional, Rigual, Nestor, additional, Baumann, Heinz, additional, and Pandey, Ravindra K., additional

Published
2011
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7. Conjugation of 2-(1′-Hexyloxyethyl)-2-devinylpyropheophorbide-a (HPPH) to Carbohydrates Changes its Subcellular Distribution and Enhances Photodynamic Activity in Vivo

Author

Zheng, Xiang, primary, Morgan, Janet, additional, Pandey, Suresh K., additional, Chen, Yihui, additional, Tracy, Erin, additional, Baumann, Heinz, additional, Missert, Joseph R., additional, Batt, Carrie, additional, Jackson, Jennifer, additional, Bellnier, David A., additional, Henderson, Barbara W., additional, and Pandey, Ravindra K., additional

Published
2009
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8. Comparative Positron-Emission Tomography (PET) Imaging and Phototherapeutic Potential of 124I- Labeled Methyl- 3-(1′-iodobenzyloxyethyl)pyropheophorbide-a vs the Corresponding Glucose and Galactose Conjugates

Author

Pandey, Suresh K., primary, Sajjad, Munawwar, additional, Chen, Yihui, additional, Zheng, Xiang, additional, Yao, Rutao, additional, Missert, Joseph R., additional, Batt, Carrie, additional, Nabi, Hani A., additional, Oseroff, Allan R., additional, and Pandey, Ravindra K., additional

Published
2008
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10. Synthesis, Photophysical Properties, Tumor Uptake, and Preliminary in Vivo Photosensitizing Efficacy of a Homologous Series of 3-(1‘-Alkyloxy)ethyl-3-devinylpurpurin-18-N-alkylimides with Variable Lipophilicity

Author

Zheng, Gang, primary, Potter, William R., additional, Camacho, Susan H., additional, Missert, Joseph R., additional, Wang, Guosheng, additional, Bellnier, David A., additional, Henderson, Barbara W., additional, Rodgers, Michael A. J., additional, Dougherty, Thomas J., additional, and Pandey, Ravindra K., additional

Published
2001
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11. In Vitro Cellular Uptake and Dimerization of Signal Transducer and Activator of Transcription-3 (STAT3) Identify the Photosensitizing and Imaging-Potential of Isomeric Photosensitizers Derived from Chlorophyll-aand Bacteriochlorophyll-a.

Author

Srivatsan, Avinash, Wang, Yanfang, Joshi, Penny, Sajjad, Munawwar, Chen, Yihui, Liu, Chao, Thankppan, Krishnakumar, Missert, Joseph R., Tracy, Erin, Morgan, Janet, Rigual, Nestor, Baumann, Heinz, and Pandey, Ravindra K.

Published
2011
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12. Comparative positron-emission tomography (PET) imaging and phototherapeutic potential of 124I- labeled methyl- 3-(1'-iodobenzyloxyethyl)pyropheophorbide-a vs the corresponding glucose and galactose conjugates.

Author

Pandey SK, Sajjad M, Chen Y, Zheng X, Yao R, Missert JR, Batt C, Nabi HA, Oseroff AR, and Pandey RK

Subjects
Animals, Chlorophyll chemistry, Chlorophyll pharmacokinetics, Chlorophyll therapeutic use, Chromatography, High Pressure Liquid, Magnetic Resonance Spectroscopy, Mass Spectrometry, Mice, Mice, Inbred BALB C, Mice, Inbred C3H, Spectrophotometry, Ultraviolet, Tissue Distribution, Chlorophyll analogs & derivatives, Galactose chemistry, Glucose chemistry, Iodine Radioisotopes therapeutic use, Photochemotherapy, Positron-Emission Tomography methods
Abstract

In our present study, 3-(1(')-m-iodobenzyloxyethyl)pyropheophorbide-a methyl ester 1, 3-(1'-m-iodobenzyloxyethyl)-17(2)-{(2-deoxy)glucose}pyropheophorbide-a 2, and 3-(1'-m-iodobenzyloxyethyl)-17(2)-{(1-deoxy)galactose}pyropheophorbide-a 3 were synthesized and converted into the corresponding (124)I-labeled analogues by reacting the intermediate trimethyltin analogues with Na(124)I. Photosensitizers 1-3 were evaluated for the PDT efficacy in C3H mice bearing RIF tumors at variable doses and showed a significant long-term tumor cure. Among the compounds investigated, the non-carbohydrate analogue 1 was most effective. These results were in contrast to the in vitro data, where compared to the parent analogue the corresponding galactose and glucose derivatives showed enhanced cell kill. Among the corresponding (124)I-labeled analogues, excellent tumor images were obtained from compound 1 in both tumor models (RIF and Colon-26) and the best tumor contrast was observed at 72 h after injection. Conjugating a glucose moiety to photosensitizer 1 initially diminished its tumor uptake, whereas with time the corresponding galactose analogue showed improved tumor contrast.

Published
2009
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13. Structure-activity relationship among purpurinimides and bacteriopurpurinimides: trifluoromethyl substituent enhanced the photosensitizing efficacy.

Author

Gryshuk A, Chen Y, Goswami LN, Pandey S, Missert JR, Ohulchanskyy T, Potter W, Prasad PN, Oseroff A, and Pandey RK

Subjects
Animals, Cell Line, Tumor, Drug Screening Assays, Antitumor, Female, Imides chemistry, Imides pharmacology, Mice, Mice, Inbred BALB C, Mice, Inbred C3H, Photochemotherapy, Photosensitizing Agents chemistry, Photosensitizing Agents pharmacology, Porphyrins chemistry, Porphyrins pharmacology, Rhodobacter sphaeroides chemistry, Solubility, Spirulina chemistry, Stereoisomerism, Structure-Activity Relationship, Water, Fluorine, Imides chemical synthesis, Photosensitizing Agents chemical synthesis, Porphyrins chemical synthesis
Abstract

At similar lipophilicity, compared to the nonfluorinated purpurinimide 11, the corresponding fluorinated analog 8 with a trifluoromethyl substituent at the lower half (position-132) of the molecule showed enhanced photosensitizing efficacy. The structural parameters established in purpurinimides (lambdamax: 700 nm) were successfully translated to the bacteriopurpurin imide system 19 (lambdamax: 792 nm) and within both series, a monotonic relationship between the lipophilicity and the in vivo PDT activity was observed. For preparing water-soluble compounds, the photosensitizers 8 and 19 were converted into the corresponding aminobenzyl-diethylenetriamine pentaacetate conjugates 23 and 26. Acid treatment of purpurinimide 23 produced the corresponding water-soluble analog 24. Bacteriochlorin 26 under acidic or basic conditions mainly gave the decomposition products. At similar in vivo treatment conditions (C3H mice with RIF tumors and BALB-C mice with colon-26 tumors) the water-soluble purpurinimide 24 was found to be more effective than the methyl ester analog 8. These results suggest that besides overall lipophilicity the inherent charge of the photosensitizer also influences the PDT efficacy.

Published
2007
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