1. Synthesis and biological activity of some 8-substituted selenoguanosine cyclic 3',5'-phosphates and related compounds
- Author
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Ming Yu Chu, Chyng Yann Shiue, and Shih Hsi Chu
- Subjects
chemistry.chemical_classification ,Leukemia, Experimental ,Stereochemistry ,Hydrolysis ,Selenourea ,Phosphodiesterase ,Biological activity ,Chemical synthesis ,Guanine Nucleotides ,Mice ,Selenium ,Cyclic nucleotide ,chemistry.chemical_compound ,chemistry ,3',5'-Cyclic-AMP Phosphodiesterases ,Drug Discovery ,Nucleic acid ,Animals ,Molecular Medicine ,Spectrophotometry, Ultraviolet ,Nucleotide ,Nucleotides, Cyclic ,Cyclic GMP ,Nucleoside - Abstract
8-Bromoguanosine cyclic 3',5'-monophosphate, 8-bromoguanosine 5'-monophosphate, and 8-bromoguanosine served as intermediates for the chemical synthesis of a series of 8-substituted seleno cyclic nucleotides, nucleotides, and their nucleosides. Selenourea was found to be a useful reagent in synthesizing these seleno-substituted nucleoside, nucleotide, and cyclic nucleotide. A nucleic acid analyzer was used to study the hydrolysis of these cyclic nucleotides by phosphodiesterase. It was found that all of the 8-substituted selenoguanosine cyclic 3',5'-phosphates synthesized, except 8-MeSe-cGMP, were resistant to hydrolyze by phosphodiesterase. These 8-substituted seleno cyclic GMP derivatives showed some antitumor activities against murine leukemic cells (L5178Y) in vitro and in vivo.
- Published
- 1975