Search

Your search keyword '"Gou, Yi"' showing total 8 results
Start Over Author "Gou, Yi" Journal journal of medicinal chemistry
8 results on '"Gou, Yi"'

5. Dithiocarbazate–FeIII, −CoIII, −NiII, and −ZnIIComplexes: Design, Synthesis, Structure, and Anticancer Evaluation

Author

Gou, Yi, Jia, Xiaoying, Hou, Li Xia, Deng, Jun Gang, Huang, Guo Jin, Jiang, Hao Wen, and Yang, Feng

Abstract

Non-platinum-metal complexes show great potential as anticancer agents. Herein, a series of dithiocarbazate non-Pt-metal complexes, including [FeIII(L)2]·Cl·2H2O 1, [CoIII(L)2]·NO3·2.5H2O 2, [NiII(L)2] 3, and [ZnII(L)2] 4, have been designed and evaluated for their efficacy as antineoplastic agents. Among them, complex 2exhibited higher anticancer efficacy than complexes 1, 3, 4, and cisplatin against several cancer cell lines. Hemolysis assays revealed that complex 2showed comparable hemolysis with cisplatin. In vivoanticancer evaluations showed that complex 2could retard tumor xenograft growth effectively with low systemic toxicity. Further studies revealed that complex 2suppressed cancer cells by triggering multiple mechanisms involving the simultaneous inhibition of mitochondria and glycolytic bioenergetics. Overall, our study provides new insights into the anticancer mechanism of Co complexes, which can be used as a good strategy to overcome the flexibility of cancer cells to chemotherapy adaptation.

Published
2022
Full Text
View/download PDF

8. Dithiocarbazate-Fe III , -Co III , -Ni II , and -Zn II Complexes: Design, Synthesis, Structure, and Anticancer Evaluation.

Author

Gou Y, Jia X, Hou LX, Deng JG, Huang GJ, Jiang HW, and Yang F

Subjects
Cisplatin pharmacology, Ferric Compounds chemistry, Hemolysis, Humans, Zinc chemistry, Antineoplastic Agents pharmacology, Antineoplastic Agents therapeutic use, Coordination Complexes pharmacology, Coordination Complexes therapeutic use, Neoplasms drug therapy
Abstract

Non-platinum-metal complexes show great potential as anticancer agents. Herein, a series of dithiocarbazate non-Pt-metal complexes, including [Fe III (L) 2 ]·Cl·2H 2 O 1 , [Co III (L) 2 ]·NO 3 ·2.5H 2 O 2 , [Ni II (L) 2 ] 3 , and [Zn II (L) 2 ] 4 , have been designed and evaluated for their efficacy as antineoplastic agents. Among them, complex 2 exhibited higher anticancer efficacy than complexes 1 , 3 , 4 , and cis platin against several cancer cell lines. Hemolysis assays revealed that complex 2 showed comparable hemolysis with cis platin. In vivo anticancer evaluations showed that complex 2 could retard tumor xenograft growth effectively with low systemic toxicity. Further studies revealed that complex 2 suppressed cancer cells by triggering multiple mechanisms involving the simultaneous inhibition of mitochondria and glycolytic bioenergetics. Overall, our study provides new insights into the anticancer mechanism of Co complexes, which can be used as a good strategy to overcome the flexibility of cancer cells to chemotherapy adaptation.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results