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Your search keyword '"Antonietta Di Cristina"' showing total 4 results
Start Over Author "Antonietta Di Cristina" Journal journal of medicinal chemistry
4 results on '"Antonietta Di Cristina"'

1. Identification of Biphenyl-Based Hybrid Molecules Able To Decrease the Intracellular Level of Bcl-2 Protein in Bcl-2 Overexpressing Leukemia Cells

Author

Stefania Grimaudo, Rosaria Maria Pipitone, Maurizio Recanatini, Manlio Tolomeo, Marinella Roberti, Antonietta Di Cristina, Daniela Pizzirani, Pizzirani D., Roberti M., Grimaudo S., Di Cristina A., Pipitone R.M., Tolomeo M., and Recanatini M.

Subjects
Antineoplastic Agents, Apoptosis, HL-60 Cells, Chemical synthesis, Structure-Activity Relationship, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Terphenyl Compounds, Drug Discovery, medicine, Humans, Spiro Compounds, Chemistry, Biphenyl Compounds, Cell Differentiation, Biological activity, Ketones, medicine.disease, In vitro, Leukemia, Proto-Oncogene Proteins c-bcl-2, Biochemistry, Cell culture, Molecular Medicine, K562 Cells, Intracellular
Abstract

With the aim of enhancing the structural complexity and diversity of an existing collection of bi- and terphenyl compounds, we synthesized hybrid molecules comprising of spirocyclic ketones (a complexity-bearing core) and bi/terphenyls (privileged fragments). Compounds 1, 3, 4, and 6 showed well-defined activity on apoptosis and differentiation, making them potential leads for development as new anticancer agents and chemical probes to study signaling networks in neoplastic cells.

Published
2009

2. Identification of a Terphenyl Derivative that Blocks the Cell Cycle in the G0−G1 Phase and Induces Differentiation in Leukemia Cells

Author

Marinella Roberti, Manlio Tolomeo, Nicola Gebbia, Daniele Simoni, Stefania Grimaudo, Antonietta Di Cristina, Daniela Pizzirani, Maurizio Recanatini, Vincenzo Abbadessa, ROBERTI M, PIZZIRANI D, RECANATINI M, SIMONI D, GRIMAUDO S, DI CRISTINA A, ABBADESSA V, GEBBIA N, TOLOMEO M, Roberti M., Pizzirani D., Recanatini M., Simoni D., Grimaudo S., Di Cristina A., Abbadessa V., Gebbia N., and Tolomeo M.

Subjects
Stereochemistry, Cellular differentiation, Fusion Proteins, bcr-abl, Antineoplastic Agents, Apoptosis, Resveratrol, Resting Phase, Cell Cycle, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Leukemia, Promyelocytic, Acute, Cell Line, Tumor, Terphenyl Compounds, Terphenyl, Stilbenes, Drug Discovery, Humans, Structure–activity relationship, ATP Binding Cassette Transporter, Subfamily B, Member 1, G1 Phase, Cell Differentiation, Cell cycle, In vitro, chemistry, Drug Resistance, Neoplasm, Cell culture, Molecular Medicine, Drug Screening Assays, Antitumor
Abstract

To further explore the SAR of resveratrol-related trans-stilbene derivatives, here we describe the synthesis of (a) a series of 3,5-dimethoxy analogues in which a variety of substituents were introduced at positions 2', 3', 4', and 5' of the stilbene scaffold and (b) a second group of derivatives (2-phenylnaphthalenes and terphenyls) that incorporate a phenyl ring as a bioisosteric replacement of the stilbene alkenyl bridge. We thoroughly characterized all of the new compounds with respect to their apoptosis-inducing activity and their effects on the cell cycle. One of the new derivatives, 13g, behaved differently from the others, as it was able to block the cell cycle in the G(0)-G(1) phase and also to induce differentiation in acute myelogenous leukemia HL60 cells. Compared to resveratrol, the synthetic terphenyl 13g showed a more potent apoptotic and differentiating activity. Moreover, it was active on both multidrug resistance and Bcr-Abl-expressing cells that were resistant to resveratrol.

Published
2006

3. Studies on the apoptotic activity of natural and synthetic retinoids: discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells

Author

Manlio Tolomeo, Stefania Grimaudo, Giuseppina Grisolia, Riccardo Baruchello, Sabrina Cavallini, Daniele Simoni, and Antonietta Di Cristina, Vincenzo Abbadessa, Francesco Paolo Invidiata, Nicola Gebbia, Riccardo Rondanin, Anna Siniscalchi, Marinella Roberti, Silvia Marino, Lucia Crosta, Giuseppe Giannini, Marcello Rossi, Stefania Aiello, Simoni D., Giannini G., Roberti M., Rondanin R., Baruchello R., Rossi M., Grisolia G., Invidiata F. P., Aiello S., Marino S., Cavallini S., Siniscalchi A., Gebbia N., Crosta L., Grimaudo S., Abbadessa V., Di Cristina A., Tolomeo M., SIMONI D, GIANNINI G, ROBERTI M, RONDANIN R, BARUCHELLO R, ROSSI M, GRISOLIA G, INVIDIATA FP, AIELLO S, MARINO S, CAVALLINI S, SINISCALCHI A, GEBBIA N, CROSTA L, GRIMAUDO S, ABBADESSA V, DI CRISTINA A, and TOLOMEO M

Subjects
Programmed cell death, Necrosis, receptor-alpha, medicine.drug_class, mechanism, Apoptosis, HL-60 Cells, necrosis, chemistry.chemical_compound, Retinoids, death, Terphenyl, Drug Discovery, medicine, Humans, Retinoid, Neurons, Cell growth, biphenyl-4-carboxylic acid, arotinoid, In vitro, Cell biology, Cultured cortical-neuron, chemistry, Biochemistry, Cell culture, retinobenzoic acid, Molecular Medicine, Indicators and Reagents, multidrug, medicine.symptom, Cell Division, (14R)-14-hydroxy-4,14-retro-retinol
Abstract

New terphenyl derivatives have been synthesized and tested for their effect on cell survival in serum-free cultures. These compounds protected HL60 cells from death and supported their growth with an activity higher than that of the natural 14-hydroxy-retro-retinol. Terphenyls 26 and 28 also possess antiapoptotic activity on neuronal cells, proving them as possible candidates for the treatment of neurodegenerative and ischemic diseases.

Published
2005

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