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We herein describe the straightforward synthesis of a stable pyridyl(4-methoxyphenyl)iodonium salt and its [ 18 F] radiolabeling within a one-step, fully automated and cGMP compliant radiosynthesis of [ 18 F]UCB-H ([ 18 F]7), a PET tracer for the imaging of synaptic vesicle glycoprotein 2A (SV2A). Over the course of 1 year, 50 automated productions provided 34 ± 2% of injectable [ 18 F]7 from up to 285 GBq (7.7 Ci) of [ 18 F]fluoride in 50 min (uncorrected radiochemical yield, specific activity of 815 ± 185 GBq/μmol). The successful implementation of our synthetic strategy within routine, high-activity, and cGMP productions attests to its practicality and reliability for the production of large doses of [ 18 F]7. In addition to enabling efficient and cost-effective clinical research on a range of neurological pathologies through the imaging of SV2A, this work further demonstrates the real value of iodonium salts for the cGMP 18 F-PET tracer manufacturing industry, and their ability to fulfill practical and regulatory requirements in that field.