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Start Over Author "Jian An Liu" Topic comparative studies Journal journal of medicinal chemistry

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1 results on '"Jian An Liu"'

1. Isocombretastatins A versus Combretastatins A: The Forgotten isoCA-4 Isomer as a Highly Promising Cytotoxic and Antitubulin Agent.

Author

Samir Messaoudi, Bret Tréguier, Abdallah Hamze, Olivier Provot, Jean-François Peyrat, Jordi Rodrigo De Losada, Jian-Miao Liu, Jérôme Bignon, Joanna Wdzieczak-Bakala, Sylviane Thoret, Joëlle Dubois, Jean-Daniel Brion, and Mouâd Alami

Subjects
*STATINS (Cardiovascular agents), *COMPARATIVE studies, *DRUG development, *ANTINEOPLASTIC agents, *OPTICAL isomers, *TUBULINS, *CHEMICAL inhibitors
Abstract

Herein is reported a convergent synthesis of isocombretastatins A, a novel class of potent antitubulin agents. These compounds having a 1,1-diarylethylene scaffold constitute the simplest isomers of natural Z-combretastatins A that are easy to synthesize without need to control the Z-olefin geometry. The discovery of isoCA-4 with biological activities comparable to that of CA-4 represents a major progress in this field. [ABSTRACT FROM AUTHOR]

Published
2009
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