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The following unique case demonstrates an episode of acute dyskinesia secondary to oral baclofen toxicity. We discuss an 80-year-old man with a history of Stage III chronic kidney disease, coronary artery disease, diabetes and stroke who presented to the Emergency Department with new onset of behavioral changes and irregular jerking movements. The patient had been recently prescribed baclofen 10mg twice daily for a back strain he suffered; he subsequently was admitted to the hospital, and his symptoms resolved within 48 hours of admission and discontinuance of baclofen., Competing Interests: Compliance with Ethical StandardsInformed ConsentConsent for publication of this case was obtained and provided to the journal in accordance with JMT policy.Conflicts of InterestThe authors declare that they have no conflicts of interest.Sources of FundingThe authors have no outside support information.