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Start Over Author "Matheux A" Journal journal of medical primatology
2 results on '"Matheux A"'

2. Chemoattractant factors (IP-10, MIP-1alpha, IL-16) mRNA expression in mononuclear cells from different tissues during acute SIVmac251 infection of macaques

Author

Frank Matheux, Arnaud Chéret, Dominique Dormont, Bruno Vaslin, F. Boussin, Roger Le Grand, Frédéric Théodora, P Caufour, and O. Neildez

Subjects
Chemokine, Lymphocyte, Simian Acquired Immunodeficiency Syndrome, medicine.disease_cause, Peripheral blood mononuclear cell, Polymerase Chain Reaction, Proinflammatory cytokine, Immune system, medicine, Animals, RNA, Messenger, Chemokine CCL4, Lymph node, Chemokine CCL3, Inflammation, Immunity, Cellular, Interleukin-16, General Veterinary, biology, Simian immunodeficiency virus, Macrophage Inflammatory Proteins, Chemokine CXCL10, Macaca fascicularis, medicine.anatomical_structure, Immunology, biology.protein, Leukocytes, Mononuclear, Animal Science and Zoology, Simian Immunodeficiency Virus, Lymph Nodes, Chemokines, Chemokines, CXC, CD8
Abstract

We have used semiquantitative RT-PCR to monitor the expression of mRNA encoding chemoattractant factors IP-10, MIP-1alpha, and IL-16 in freshly isolated peripheral blood mononuclear cells (PBMCs), lymph node mononuclear cells (LNMCs), and mononuclear cells obtained after bronchoalveolar lavages (BALMCs) of two cynomolgus macaques inoculated intravenously with a pathogenic isolate of simian immunodeficiency virus, SIVmac251. Concomitant with the peak of systemic viral replication (two weeks after experimental inoculation) and proinflammatory cytokine IL-6 mRNA expression, high levels of MIP-1alpha and IP-10 mRNA were produced in LNMCs and BALMCs. In BALMCs, in which we have reported a marked progressive overexpression of IFN-gamma mRNA coinciding with an increase in the CD8+ lymphocyte percentages, we noticed a progressive overexpression of IL-16 mRNA. Our results suggest the role of chemokines IP-10, MIP-1alpha, and IL-16 in the development of inflammatory and immune responses during the early stages of lentiviral infection.

Published
1997

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