1. Cervical ripening and uterine contraction induced by prostaglandin E2-gel in pregnant Japanese monkeys (Macaca fuscata fuscata)
- Author
-
Kiyoshi Oshima, Masumi Nozaki, and Keiko Shimizu
- Subjects
medicine.medical_specialty ,Uterus ,Connective tissue ,Cervix Uteri ,Biology ,Dinoprost ,Dinoprostone ,Uterine contraction ,Uterine Contraction ,Route of administration ,Pregnancy ,Internal medicine ,medicine ,Animals ,Prostaglandin E2 ,Cervix ,General Veterinary ,Ripening ,Heart Rate, Fetal ,medicine.anatomical_structure ,Endocrinology ,In utero ,Macaca ,Pregnancy, Animal ,Female ,lipids (amino acids, peptides, and proteins) ,Animal Science and Zoology ,Collagen ,medicine.symptom ,medicine.drug - Abstract
Effects of intracervical administration of PGE2-gel were studied in pregnant Japanese monkeys (Macaca fuscata fuscata) near term. Administration of PGE2-gel induced cervical ripening and an increase in maternal plasma PGE2 but no change in PGF2 alpha. Ultrastructural observations of the connective tissue of the cervix after PGE2-gel treatment revealed a decrease in the number of collagenous fibers. These results show that intracervical administration of PGE2-gel induces cervical ripening without induction of labor in the Japanese monkey.
- Published
- 1994
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