This special issue emerges as a result of papers delivered at the 1st International Health Humanities Conference: Madness & Literature, funded by the Arts and Humanities Research Council, UK, and held at the Institute of Mental Health at the University of Nottingham, August 6–8, 2010. The conference, which included keynotes from Elaine Showalter (The Female Malady) and Kay Redfield Jamison (Touched By Fire), was hosted as part of a range of initiatives based at the University of Nottingham which we call ‘Health Humanities’—an evolution of Medical Humanities towards greater inclusion of and engagement with allied health professionals including nurses, occupational therapists and those practicing the expressive therapies, as well as carers, service-users and a wider selfcaring public. Our aim is to address the growing and broadening demand from other professions to become involved and to include new sectors of the healthcare workforce, as well as informal carers who have often been left out of the medical humanities so far. Different disciplines have increasingly come to value the contribution made by the humanities, and fresh opportunities are emerging in healthcare for the development of new approaches in the humanities. Our conference was a landmark attempt to bring some of these ideas together. Focussing on madness in all its guises, it was accompanied by a new website, www. madnessandliterature.org, which has so far attracted over 300 academic, clinical and lay members worldwide and offers numerous short reviews of ‘Mad Literature’ or ‘Mad Lit.’—fiction and autobiography that documents and details a diverse range of human experience that falls within the category madness. Why is ‘Mad Lit.’ generating such interest? As we note in our book, Madness in Post1945 British and American Fiction (Baker et al. 2010), it provides valuable and sometimes contrasting insights into the traumatising experience of mental illness, attitudes towards individuals deemed ill, and the treatments, social networks, institutions and historical or J Med Humanit (2011) 32:253–255 DOI 10.1007/s10912-011-9157-1