1. Different fetal-neonatal outcomes in siblings born to a mother with Graves-Basedow disease after total thyroidectomy: a case series
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Giovanni Alighieri, Maria Pia De Carolis, Sabrina Perrone, Paola Sindico, Costantino Romagnoli, Patrizia Papacci, Antonio Alberto Zuppa, Francesco Cota, Valentina Cardiello, Eleonora Antichi, and Chiara Carducci
- Subjects
Total thyroidectomy ,Medicine(all) ,Pediatrics ,medicine.medical_specialty ,Fetus ,endocrine system ,endocrine system diseases ,Graves-basedow ,Offspring ,business.industry ,lcsh:R ,lcsh:Medicine ,General Medicine ,Thyrotropin receptor ,Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA ,Neonatal outcomes ,Case report ,medicine ,Basedow Disease ,business ,hormones, hormone substitutes, and hormone antagonists - Abstract
Introduction We describe three different fetal or neonatal outcomes in the offspring of a mother who had persistent circulating thyrotropin receptor antibodies despite having undergone a total thyroidectomy several years before. Case presentation The three different outcomes were an intrauterine death, a mild and transient fetal and neonatal hyperthyroidism and a severe fetal and neonatal hyperthyroidism that required specific therapy. Conclusions The three cases are interesting because of the different outcomes, the absence of a direct correlation between thyrotropin receptor antibody levels and clinical signs, and the persistence of thyrotropin receptor antibodies several years after a total thyroidectomy.
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