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Objective: To describe gender distribution in fetuses with increased nuchal translucency (NT) measurements. Methods: All fetuses with mild (2.5-2.9 mm) and moderate (3.0-3.5 mm) NT enlargement at 12.0-12.6 weeks gestation were studied. The Z test for proportions was used to compare the gender distribution of this study group to that of all babies born at Roosevelt Hospital in 2008, and to compare the gender distributions of the subgroups. Results: 5109 patients received screening at 12.0-12.6 weeks gestation. 44 fetuses had mild and 28 had moderate enlargement, with a male-to-female ratio of 3.8:1.0, much higher than the 1.06:1.0 ratio among total births at Roosevelt Hospital in 2008 ( p < 0.0001). Male-to-female ratio was 7.8:1.0 in fetuses with mild and 1.8:1.0 with moderate NT enlargement ( p = 0.03). Among fetuses with mild NT enlargement, 3 males had aneuploidy; among those with moderate enlargement, 6 fetuses had aneuploidy, 3 males and 3 females. Seven pregnancies with aneuploidy were voluntarily terminated. All pregnancies carried to term were healthy. Conclusions: More males than females had mild NT enlargement on first-trimester screening, but unless aneuploidy was detected they had normal birth outcomes. A slightly larger NT may be normal in males, while indicating possible fetal abnormalities in females. [ABSTRACT FROM AUTHOR]

Objective. To determine whether first-trimester crown-rump length (CRL) is associated with birthweight extremes at term. Methods. Included in this study were all term, small for gestational age (SGA), and large for gestational age (LGA) neonates with no other obstetric complications and no abnormal outcomes of pregnancy. CRL at 12.0 to 12.6 weeks of estimated gestational age obtained during nuchal translucency screening was selected as an estimate of early fetal growth. Mean first-trimester CRL of the LGA noenates at term was compared via student's t-test with mean first-trimester CRL of SGA neonates at term. Results. In all, 121 neonates were included in the study. Mean first-trimester CRL of the 63 LGA-term neonates was 62.7 ± 6.0 mm (95%% confidence interval, ±1.49 mm; range, 61.21-64.19), while that of the 58 SGA-term neonates was smaller at 58.8 ± 6.9 mm (95%% confidence interval, ±1.79 mm; range, 57.01-60.59 mm). This 3.9 mm difference between the means was statistically significant ( P == 0.01). Conclusion. We found that birthweights of LGA and SGA neonates at term were associated with their first-trimester CRL measurements, thus, indicating that fetal growth patterns apparent early in pregnancy continue through term. [ABSTRACT FROM AUTHOR]