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Your search keyword '"He, Jiecheng"' showing total 4 results
Start Over Author "He, Jiecheng" Journal journal of materials chemistry b
4 results on '"He, Jiecheng"'

3. Multi-ligand modified PC@DOX-PA/EGCG micelles effectively inhibit the growth of ER+, PR+ or HER2+ breast cancer.

Author

Wang, Xiaozhen, He, Jiecheng, Jiang, Siyuan, Gao, Yifei, Zhang, Ling-Kun, Yin, Liang, You, Rong, and Guan, Yan-Qing

Abstract

Breast cancer is one of the most common cancers in the world with tumor heterogeneity. Currently, cancer treatment mainly relies on surgical intervention, chemotherapy, and radiotherapy, for which the side effects, drug resistance and cost need to be resolved. In this study, we develop a natural medicine targeted therapy system. Phosphatidylcholine (PC), doxorubicin (DOX), procyanidin (PA), and epigallocatechin gallate (EGCG) are assembled and PC@DOX-PA/EGCG nanoparticles (NPs) are obtained. In addition, the HER2, ER and PR ligands were grafted on the surface of the NPs to acquire the targeted nanoparticles NP-ER, NP-ER-HER2, and NP-ER-HER2-PR. The physicochemical properties of the nanoparticles were detected and it was found that the nanoparticles are spherical and less than 200 nm in diameter. Furthermore, in vitro and in vivo results indicate that the nanoparticles can target BT-474, MCF-7, EMT-6, and MDA-MB-231 breast cancer cells, effectively inhibiting the growth of the breast cancer cells. In short, this research will provide some strategies for the treatment of heterogeneous breast cancer. [ABSTRACT FROM AUTHOR]

Published
2022
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4. Multi-ligand modified PC@DOX-PA/EGCG micelles effectively inhibit the growth of ER + , PR + or HER 2+ breast cancer.

Author

Wang X, He J, Jiang S, Gao Y, Zhang LK, Yin L, You R, and Guan YQ

Subjects
Animals, Antineoplastic Agents chemistry, Apoptosis drug effects, Biflavonoids chemistry, Catechin analogs & derivatives, Catechin chemistry, Cell Line, Tumor, Cell Proliferation drug effects, Doxorubicin chemistry, Drug Carriers chemical synthesis, Drug Liberation, Humans, Ligands, Mice, Inbred BALB C, Phosphatidylcholines chemistry, Proanthocyanidins chemistry, Mice, Antineoplastic Agents therapeutic use, Breast Neoplasms drug therapy, Doxorubicin therapeutic use, Drug Carriers chemistry, Micelles
Abstract

Breast cancer is one of the most common cancers in the world with tumor heterogeneity. Currently, cancer treatment mainly relies on surgical intervention, chemotherapy, and radiotherapy, for which the side effects, drug resistance and cost need to be resolved. In this study, we develop a natural medicine targeted therapy system. Phosphatidylcholine (PC), doxorubicin (DOX), procyanidin (PA), and epigallocatechin gallate (EGCG) are assembled and PC@DOX-PA/EGCG nanoparticles (NPs) are obtained. In addition, the HER2, ER and PR ligands were grafted on the surface of the NPs to acquire the targeted nanoparticles NP-ER, NP-ER-HER2, and NP-ER-HER2-PR. The physicochemical properties of the nanoparticles were detected and it was found that the nanoparticles are spherical and less than 200 nm in diameter. Furthermore, in vitro and in vivo results indicate that the nanoparticles can target BT-474, MCF-7, EMT-6, and MDA-MB-231 breast cancer cells, effectively inhibiting the growth of the breast cancer cells. In short, this research will provide some strategies for the treatment of heterogeneous breast cancer.

Published
2022
Full Text
View/download PDF

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