1. Surface-assisted laser desorption and ionization mass spectrometry using low-cost matrix-free substrates
- Author
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Mengyan Shen, Steven M. Ebstein, Howard Guthermann, and Haibin Huo
- Subjects
Chemistry ,Angiotensin II ,Polyurethanes ,Surface plasmon ,Analytical chemistry ,Surface Plasmon Resonance ,Laser ,Mass spectrometry ,Soft laser desorption ,Nanostructures ,law.invention ,Nanolithography ,Adrenocorticotropic Hormone ,law ,Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ,Desorption ,Ionization ,Microscopy, Electron, Scanning ,Nanotechnology ,Gold ,Spectroscopy - Abstract
Surface-assisted laser desorption/ionization (SALDI) substrates have been fabricated using nanospiked polyurethane (PU) substrates that are replicated by a low-cost soft nanolithography method from silicon nanospike structures formed with femtosecond laser irradiations. The strongest mass spectrometry (MS) signal of Angiotensin II was obtained on 45-nm Au-coated nanospiked PU substrates. The effective ionization appears to be due to surface plasmon excitation. Such low-cost and identical SALDI substrates can be used for MS analysis of various molecules with high reproducibility. Copyright © 2011 John Wiley & Sons, Ltd.
- Published
- 2011
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