1. Proton MR spectroscopy in quantitative in vivo determination of fat content in human liver steatosis.
- Author
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Longo R, Pollesello P, Ricci C, Masutti F, Kvam BJ, Bercich L, Crocè LS, Grigolato P, Paoletti S, and de Bernard B
- Subjects
- Adult, Aged, Fatty Liver diagnostic imaging, Fatty Liver pathology, Feasibility Studies, Female, Humans, Liver diagnostic imaging, Liver pathology, Magnetic Resonance Spectroscopy, Male, Middle Aged, Protons, Regression Analysis, Tomography, X-Ray Computed, Fatty Liver metabolism, Lipids analysis, Liver chemistry
- Abstract
To demonstrate that the lipid volume fraction in liver steatosis can be accurately estimated with in vivo hydrogen-1 magnetic resonance (MR) spectroscopy, the authors developed a calibration procedure based on in vitro MR spectroscopy of lipid extracts from steatotic liver specimens. The lipid volume fractions determined with the calibration procedure were compared with the results of histomorphometry and with calibrated computed tomographic (CT) data. The volume fraction of fat determined with MR spectroscopy was in good agreement with the CT results, whereas histomorphometry underestimated the amount of hepatic fat. The results indicate that determination of the fat volume fraction in steatotic liver can be achieved noninvasively with MR spectroscopy.
- Published
- 1995
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