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Start Over Author "Storm, G." Journal journal of liposome research
14 results on '"Storm, G."'

1. Poster Abstracts

Author

Littger, Ralf, primary, Alke, Alexandra, additional, Tewes, Bernhard, additional, Gropp, Felix, additional, Asai, T., additional, Watanabe, K., additional, Kuromi, K., additional, Kurohane, K., additional, Ogino, K., additional, Taki, T., additional, Tsukada, H., additional, Nakayama, J., additional, Oku, N., additional, Babai, I., additional, Matyas, G., additional, Baranji, L., additional, Milosevits, J., additional, Alving, C. R., additional, Bendas, G., additional, Rothe, U., additional, Scherphof, G. L., additional, Kamps, J. A. A. M., additional, Kessner, S., additional, Carafa, M., additional, Di Stefano, A., additional, Sozio, P., additional, Cacciatore, I., additional, Mosciatti, B., additional, Santucci, E., additional, Choice, E., additional, Harvie, P., additional, Galbraith, T., additional, Zunder, E., additional, Dutzar, B., additional, Anklesaria, P., additional, Paul, R., additional, Cocquyt, J., additional, De Cuyper, M., additional, Van der Meeren, P., additional, Cruz, M. E. M., additional, Gaspar, M. M., additional, Silva, M. T., additional, Dathe, M., additional, Nikolenko, H., additional, Wessolowski, A., additional, Schmieder, P., additional, Beyermann, M., additional, Bienert, M., additional, Santos, N. Dos, additional, Cox, K. A., additional, Allen, C., additional, Gallagher, R. C., additional, Ickenstein, L., additional, Mayer, L. D., additional, Bally, M. B., additional, Fischer, S., additional, Margalit, R., additional, Freisleben, H.-J., additional, Garidel, P., additional, Chen, H. C., additional, Moore, D., additional, Mendelsohn, R., additional, Keller, M., additional, Hildebrand, A., additional, Blume, A., additional, Girão da Cruz, M. T., additional, Simões, S., additional, Pedroso de Lima, M. C., additional, Graser, A., additional, Nahde, T., additional, Fahr, A., additional, Müller, R., additional, Müller-Brüsselbach, S., additional, Cudmore, S., additional, O'Mahony, D., additional, Hoving, S., additional, van Tiel, S. T., additional, Seynhaeve, A. L. B., additional, Ambagtsheer, G., additional, Eggermont, A. M. M., additional, ten Hagen, T. L. M., additional, Høyrup, P., additional, Jensen, S. S., additional, Jørgensen, K., additional, Iden, D., additional, Kuang, H., additional, Mullen, P., additional, Jacobs, C., additional, Roben, P., additional, Stevens, T., additional, Lollo, C., additional, Ishida, T., additional, Maeda, R., additional, Masuda, K., additional, Ichihara, M., additional, Kiwada, H., additional, Jung, K., additional, Reszka, R., additional, Kaiser, N., additional, Ohloff, I., additional, Linser-Haar, S., additional, Massing, U., additional, Schubert, R., additional, Kan, P., additional, Tsao, C. W., additional, Chen, W. K., additional, Wang, A. J., additional, Kimpfler, A., additional, Gerber, C., additional, Wieschollek, A., additional, Bruchelt, G., additional, Kobayashi, T., additional, Okada, Y., additional, Sone, S., additional, Harashima, H., additional, Maruyama, K., additional, Kondo, Masayo, additional, Lee, Chun Man, additional, Tanaka, Toshiyuki, additional, Su, Wei, additional, Kitagawa, Toru, additional, Ito, Toshinori, additional, Matsuda, Hikaru, additional, Murai, Toshiyuki, additional, Miyasaka, Masayuki, additional, Junji, Kimura, additional, Kondo, Masami, additional, Asai, Tomohiro, additional, Ogino, Koichi, additional, Taki, Takao, additional, Tsukada, Hideo, additional, Baba, Kazuhiko, additional, Oku, Naoto, additional, Koning, G. A., additional, Wauben, M. H. M., additional, Vestweber, D., additional, Everts, M., additional, Kok, R. J., additional, Schraa, A. J., additional, Molema, G., additional, Schiffelers, R. M., additional, Storm, G., additional, Kristl, J., additional, Šentjurc, M., additional, Abramović, Z., additional, Landry, S., additional, Perron, S., additional, Bestman-Smith, J., additional, Désormeaux, A., additional, Tremblay, M. J., additional, Bergeron, M. G., additional, Madeira, C., additional, Loura, L. M. S., additional, Fedorov, A., additional, Prieto, M., additional, Aires-Barros, M. R., additional, Marques, C. M., additional, Simões, S. I., additional, Cruz, M. E., additional, Cevc, G., additional, Martins, M. B., additional, Moreira, J. N., additional, Gaspar, R., additional, Allen, T. M., additional, Esposito, C., additional, Ortaggi, G., additional, Bianco, A., additional, Bonadies, F., additional, Malizia, D., additional, Napolitano, R., additional, Cametti, C., additional, Mossa, G., additional, Endert, Gerold, additional, Essler, Frank, additional, Lutz, Silke, additional, Panzner, Steffen, additional, Pastorino, F., additional, Brignole, C., additional, Pagnan, G., additional, Moase, E. H., additional, Ponzoni, M., additional, Pavelic, Z., additional, Škalko-Basnet, N., additional, Jalšenjak, I., additional, Penacho, N., additional, Pisano, C., additional, Bucci, F., additional, Serafini, S., additional, Martinelli, R., additional, Cupelli, A., additional, Marconi, A., additional, Ferrara, F. F., additional, Santaniello, M., additional, Critelli, L., additional, Tinti, O., additional, Luisi, P., additional, Carminati, P., additional, Galletti, B., additional, Sauer, I., additional, Schleef, M., additional, Voß, C., additional, Schmidt, T., additional, Flaschel, E., additional, König, S., additional, Wenger, T., additional, Dumond, J., additional, Bogetto, N., additional, Reboud-Ravaux, M., additional, Schramm, H. J., additional, Schramm, W., additional, Sheynis, T., additional, Rozner, S., additional, Kolusheva, S., additional, Satchell, D., additional, Jelnik, R., additional, Shigeta, Y., additional, Imanaka, H., additional, Ando, H., additional, Makino, T., additional, Baba, N., additional, Shimizu, K., additional, Takada, M., additional, Baba, K., additional, Namba, Y., additional, Simberg, Dmitri, additional, Danino, Dganit, additional, Talmon, Yeshayahu, additional, Minsky, Abraham, additional, Ferrari, Marilyn E., additional, Wheeler, Carl J., additional, Barenholz, Yechezkel, additional, Takada, Miki, additional, Shimizu, Kosuke, additional, Kuromi, Koici, additional, Takeuchi, Y., additional, North, J. R., additional, Nango, M., additional, Tewes, B., additional, Köchling, T., additional, Deissler, M., additional, Kühl, C., additional, Marx, U., additional, Strote, G., additional, Gropp, F., additional, Qualls, Marquita M., additional, Kim, Jong-Mok, additional, Thompson, David H., additional, Zhang, Zhi-Yi, additional, Shum, Pochi, additional, Collier, Joel H., additional, Hu, Bi-Huang, additional, Ruberti, Jeffrey W., additional, Messersmith, Phillip B., additional, Tsuruda, T., additional, Nakade, A., additional, Sadzuka, Y., additional, Hirota, S., additional, Sonobe, T., additional, Vorauer-Uhl, K., additional, Wagner, A., additional, Katinger, H., additional, Weeke-Klimp, A. H., additional, Bartsch, M., additional, Meijer, D. K. F., additional, Zeisig, R., additional, Walther, W., additional, Reß, A., additional, Fichtner, I., additional, Zschörnig, O., additional, Schiller, J., additional, Süß, M., additional, Bergmeier, C., additional, Arnold, K., additional, Nchinda, Godwin, additional, Überla, Klaus, additional, and Zschörnig, Olaf, additional

Published
2003
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2. Oral Presentations—Abstracts

Author

Bartsch, M., primary, Meijer, D. K. F., additional, Scherphof, G. L., additional, Kamps, J. A. A. M., additional, Erdoğan, S., additional, Özer, A. Y., additional, Caner, B., additional, Bilgili, H., additional, Ickenstein, L. M., additional, Edwards, K., additional, Karlsson, G., additional, Mayer, L. D., additional, Eley, Crispin G. S., additional, Hu, Ning, additional, Jensen, Gerard M., additional, Kawahara, K., additional, Sekiguchi, A., additional, Kiyoki, E., additional, Morimoto, K., additional, Boerman, O. C., additional, Miyajima, M., additional, Kimura, J., additional, Koning, G. A., additional, Morselt, H. W. M., additional, Metselaar, Josbert M., additional, Wauben, Marca H. M., additional, Boerman, Otto C., additional, van Lent, Peter L., additional, Storm, Gert, additional, Pastorino, F., additional, Brignole, C., additional, Marimpietri, D., additional, Moase, E. H., additional, Allen, T. M., additional, Ponzoni, M., additional, Romøren, K., additional, Thu, B. J., additional, Evensen, Ø, additional, Rossi, S., additional, Ristori, S., additional, Martini, G., additional, Schiffelers, R. M., additional, Molema, G., additional, ten Hagen, T. L. M., additional, Janssen, A. P. C. A., additional, Ebben, R. G., additional, Schraa, A. J., additional, Kok, R. J., additional, Koning, G., additional, Storm, G., additional, Simões, S. I., additional, Marques, C. M., additional, Cruz, M. E., additional, Cevc, G., additional, Martins, M. B., additional, Summers, D., additional, Ruff, D., additional, Smalling, R. W., additional, Cardoza, D., additional, Dottavio, D., additional, Lasic, D., additional, Szebeni, J., additional, Baranyi, L., additional, Savay, S., additional, Milosevits, J., additional, Bunger, R., additional, Laverman, P., additional, Metselaar, J. M., additional, Chanan-Khan, A., additional, Liebes, L., additional, Muggia, F. M., additional, Cohen, R., additional, Barenholz, Y., additional, Alving, C. R., additional, Hoving, S., additional, Seynhaeve, A. L. B., additional, van Tiel, S. T., additional, Eggermont, A. M. M., additional, Tokutomi, K., additional, Sadzuka, Y., additional, Igarashi, A., additional, Konno, H., additional, and Sonobe, T., additional

Published
2003
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3. ROLE OF COMPLEMENT ACTIVATION IN HYPERSENSITIVITY REACTIONS TO DOXIL AND HYNIC PEG LIPOSOMES: EXPERIMENTAL AND CLINICAL STUDIES

Author

Szebeni, J., primary, Baranyi, L., additional, Savay, S., additional, Milosevits, J., additional, Bunger, R., additional, Laverman, P., additional, Metselaar, J. M., additional, Storm, G., additional, Chanan-Khan, A., additional, Liebes, L., additional, Muggia, F. M., additional, Cohen, R., additional, Barenholz, Y., additional, and Alving, C. R., additional

Published
2002
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9. Utility of targeted glucocorticoids in cancer therapy.

Author

Banciu M, Schiffelers RM, Metselaar JM, and Storm G

Subjects
Animals, Antineoplastic Agents administration & dosage, Drug Delivery Systems, Genomics, Humans, Inflammation, Liposomes metabolism, Models, Biological, Neovascularization, Pathologic, Transcription, Genetic, Glucocorticoids therapeutic use, Liposomes chemistry, Neoplasms therapy
Abstract

Glucocorticoids can inhibit solid tumor growth via downregulation of tumor-associated inflammation/angiogenesis. In this minireview we describe the possible mechanisms of glucocorticoid action in tumor growth inhibition. We also present an overview of the current status of tumor-targeted glucocorticoid delivery. It appears that long-circulating liposomes are the only targeting system currently being explored for this purpose.

Published
2008
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10. Therapeutic application of long-circulating liposomal glucocorticoids in auto-immune diseases and cancer.

Author

Schiffelers RM, Banciu M, Metselaar JM, and Storm G

Subjects
Animals, Glucocorticoids administration & dosage, Glucocorticoids pharmacokinetics, Humans, Autoimmune Diseases blood, Glucocorticoids blood, Liposomes, Neoplasms blood
Abstract

Glucorticoids are potent drugs that have a multitude of pharmacological actions both at genomic and non-genomic levels. Many of the diseases in which glucorticoids are routinely administered are featured by angiogenesis and enhanced capillary permeability, permitting targeted delivery using long-circulating drug delivery systems. By encapsulation of glucorticoids in long-circulating liposomes, drug levels at the site of the pathology are markedly higher, increasing and prolonging therapeutic efficacy in models of rheumatoid arthritis, multiple sclerosis, and cancer.

Published
2006
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11. Liposomes: from the bench to the bed.

Author

Crommelin DJ and Storm G

Subjects
Animals, Drug Stability, Humans, Quality Control, Technology, Pharmaceutical methods, Chemistry, Pharmaceutical standards, Liposomes, Technology, Pharmaceutical standards
Published
2003
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12. Targeted liposomes for delivery of protein-based drugs into the cytoplasm of tumor cells.

Author

Mastrobattista E, Crommelin DJ, Wilschut J, and Storm G

Subjects
Endosomes, Flow Cytometry, Humans, Hydrogen-Ion Concentration, Lipids chemistry, Liposomes chemistry, Models, Biological, Orthomyxoviridae physiology, Peptides chemistry, Protein Binding, Tumor Cells, Cultured, Cytoplasm metabolism, Drug Delivery Systems, Liposomes metabolism
Abstract

Our goal was to deliver therapeutically active macromolecules into the cytosol of target cells. First, attempts were made to prepare virosomes that specifically interact with OVCAR-3 cells (human ovarian cancer cells). Detergent solubilized influenza virus envelopes were reconstituted forming virosomes. Cell specificity was introduced by incorporating PEG-derivatized lipids with mAB 323/A3 (Fab' fragments) connected to their distal PEG end. These cell-specific, modified virosomes maintained their fusogenic activity when lowering the pH. Most importantly, antibody-mediated binding was a prerequisite for low-pH induced membrane fusion. However, basically, there are two problems with this approach: (1) these virosomes are quite leaky and (2) virosomes can be expected to be immunogenic. A solution to tackle leakage and potential immunogenicity of these site-specific liposomal structures is to use immuno-PEG-liposomes with a pH-dependent fusogen inside the liposome. The system that we designed to test this concept consisted of (1) the fusogenic di-peptide dINF-7, (2) the monoclonal antibody 425 connected to the distal end of PEG-PE (for site specific binding and endosomal uptake), (3) diphtheria toxin chain A (DTA, as carrier-dependent active compound) and phosphatidylcholine/cholesterol as 'bilayer backbone'. A series of tests were performed to show that selective binding and pH-dependent destabilization of (endosomal) membranes indeed occurred. To test the cytotoxic activity of these DTA loaded liposomes, OVCAR-3 cells were used for testing. OVCAR-3 cells express the epidermal growth factor receptor, which is the ligand for antibody 425. In vitro, these site specific and fusogenic liposomes showed a remarkable, cell specific cytotoxic effect.

Published
2002
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13. Liposome-enabled synergistic interaction of antimicrobial agents.

Author

Schiffelers RM, Storm G, ten Kate MT, Stearne-Cullen LE, den Hollander JG, Verbrugh HA, and Bakker-Woudenberg IA

Subjects
Animals, Ceftazidime administration & dosage, Dose-Response Relationship, Drug, Drug Compounding, Gentamicins administration & dosage, Klebsiella pneumoniae metabolism, Polyethylene Glycols chemistry, Rats, Tissue Distribution, Anti-Bacterial Agents administration & dosage, Liposomes metabolism
Abstract

Antimicrobial agents may interact synergistically when both drugs are present at the infected site for an adequate period of time at sufficient concentrations. Generally speaking, the agents in the combination show different tissue distributions and pharmacokinetics. By co-encapsulation of the drugs in a drug carrier, like liposomes, parallel tissue distributions of both drugs may be ensured and drug concentrations at the site of infection may be increased. In this presentation therapeutic efficacy of liposome-co-encapsulated gentamicin (GN) and ceftazidime (CZ) will be shown in a GN-CZ-susceptible and GN-CZ-resistant Klebsiella pneumoniae-pneumonia in rats.

Published
2002
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14. Ligand-targeted liposomes directed against pathological vasculature.

Author

Schiffelers RM, Molema G, ten Hagen TL, Janssen AP, Schraa AJ, Kok RJ, Koning GA, and Storm G

Subjects
Cells, Cultured, Doxorubicin pharmacology, Endothelium, Vascular cytology, Humans, Inflammation, Integrin alphaVbeta3 metabolism, Integrins metabolism, Ligands, Oligopeptides pharmacology, Polyethylene Glycols metabolism, Umbilical Veins cytology, Liposomes metabolism, Neovascularization, Pathologic drug therapy
Abstract

The development of liposomes targeted to angiogenic endothelial cells offers exciting prospects for intervention in cancer and inflammation. Several proteins are (strongly) over-expressed on angiogenic endothelial cells as compared to the quiescent endothelium, and could potentially serve as targets for site-specific drug delivery. In this contribution particular attention is given to the design of targeted long-circulating liposomes directed against the alpha v beta 3-integrin protein.

Published
2002
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