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Start Over Author "Chi-Tung Hsu" Journal journal of labelled compounds and radiopharmaceuticals
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1. Synthesis of 2-(bromomethyl-13C)-fumaric acid (bromomesaconic acid)

Author

D. John Aberhart and Chi-Tung Hsu

Subjects
Fumaric acid, Organic Chemistry, Bromomesaconic acid, Citraconate, Biochemistry, Analytical Chemistry, chemistry.chemical_compound, chemistry, Fumarase, Drug Discovery, Trifluoroacetic acid, Organic chemistry, Radiology, Nuclear Medicine and imaging, Isomerization, Spectroscopy
Abstract

The fumarase inhibitor, bromomescaconic acid, has been synthesized with 13C labeling in the bromomethyl group. Di-t-butyl acetylene-dicarboxylate was converted with Li (13CH3)2Cu to di-t-butyl (methyl-13C)citraconate. Photochemical isomerization of this to di-t-butyl (methyl-13C)mesaconate, followed by deblocking with trifluoroacetic acid gave the title compound.

Published
1981

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