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Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the genetic polymorphism of 18 autosomal short tandem repeats (STR) loci in 2 323 healthy unrelated individuals of Minjia branch of Bai nationality in Yunnan, calculate the population genetic parameters, and establish the genetic data of Minjia branch of Bai nationality in Yunnan, so as to provide the scientific basis for the parental identification and individual identification of forensic material evidence. Methods A total of 2 323 unrelated individuals from Minjia branch of Bai nationality population were collected. DNA TyperTM 19 kit was used for direct PCR compound amplification. AB 3130XL automatic genetic analyzer was used to separate the PCR compound amplification products by capillary electrophoresis. STR typing was performed with GeneMapper ID-x 1.5 software. Forensic parameters, such as allele frequency and matching probability, were calculated by Modified Powerstats software, and the hardy-Weinberg equilibrium (HWE) test was performed. The Fst and P values were calculated using Arlequin software. Nei’ s genetic distance was calculated using Phylip software. Multi-dimensional scale (MDS) analysis was performed using SPSS software. The Neighbor-Joining (NJ) phylogenetic tree was constructed by Mega software. Results A total of 230 alleles and 1 073 genotypes were observed at 18 STR loci. Except that D13S317 loci was not in accord with Hardy-Weinberg equilibrium ( P = 0.000 8）, the allele frequencies and genotype frequencies of other loci were consistent with Hardy-Weinberg equilibrium (P > 0.05/20 = 0.002 5）. The cumulative discrimination power (CDP) and cumulative probability of exclusion (CPE) of 18 STR loci were 0.999 999 999 and 0.999 999 940 55, respectively. The results of Fst, Nei’s genetic distance and NJ phylogenetic tree indicated that the Minjia branch of Bai nationality was close to the Bai nationality in Nujiang and the Bai nationality in Dali, but far away from the Bulang nationality in Yunnan and Va nationality in Yunnan. Conclusion The 18 STR loci mentioned above show the high genetic polymorphism in the Minjia branch of Bai nationality and they can be used for the forensic identification and population genetics research [ABSTRACT FROM AUTHOR]

Objective Through visiting the patients with atrial fibrillation who are accepting the anticoagulation therapy of warfarin， and retrospectively analyzing multiple factors which effected warfarin dosing and relationship of dosing and INR，we try to discuss a technique of effective and safe application of warfarin. Methods Retrospective analysis of hospital records were taken from 45 patients with primary diagnosis of AF. Patients enrolled were devided into group A with a starting dose of 1.25 mg/d or 1.5 mg/d， group B 2.5 mg/d or 3 mg/d. Acoording to maintaining dose， group C with a maintaining dose of less than 2 mg/d， group D 2∼3.5 mg/d，and group E exceeding 3.5 mg/d. In the case of dose unchanged， it's considered as reaching the mark when INR stability in 2.0∼3.0. Results the percentage of INR up to the standards， in group A 14.3％，group B 48.2％， group A was higher than the B （ = 0.018） .The values of INR were not statistically significant between group C，D and E. C group detected a total of six times greater than 3.0 （12.0％），D and E respectively 3.0％ and 2.0％， there are different between the value of a statistical significance. Each group's average maintaining dose was different in statistics（C as 0.738±0.152 mg/INR， D as 1.230±0.267 mg/INR，E as 2.056±0.379 mg/INR， ＜0.001）. Conclusion AF patients who choose 2.5 mg/d or 3 mg/d as a starting warfarin dose possess of higher INR standardized rate than chose who received lower dose，and furthermore，it dosen't increase the incidence of overanticoagulation. Patients who hold lower maintaining dose are more tendential of over-anticoagulation （INR＞3.0）. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

亚健康状态是临床常见的一种病症，近年来在我国的发病率有明显增加的趋势，而且逐渐年轻化 [1] ．笔者于2008 年 4 月 至 2013 年 6 月采用中西医结合疗法治疗亚健康状态 60 例，疗效满意，现报道如下. [ABSTRACT FROM AUTHOR]