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Objective　 To investigate the clinical characteristics of female patients with myocardial infarction and the differences in serum levels of endoplasmic reticulum stress proteins HSP47， XBP-1S， and GRP78 with male patients. Methods　 A total of 356 patients with acute myocardial infarction who were admitted to the hospital. The venous blood was collected within 24 hours after the onset，and the serum HSP47，XBP-1S and GRP78 concentrations were measured after centrifugation. They were divided into female group （n = 116） and male group （ n = 240） . The independent sample t test，chi-square test and nonparametric rank sum test were used for clinical data analysis. Results　 The age of onset in the female group was older than that in the male group （P < 0.05）； while the prevalence of smoking and hypertension in the female group were lower than those in the male group （P < 0.05）. The level of XBP-1S in serum of female patients was higher than that of male patients （P = 0.023， P < 0.05）；but there was no significant difference in serum HSP47 and GRP78 levels between female patients and male patients （P > 0.05）. Serum GLU and BNP levels in the female patient group were higher than those in the male patient group （both P < 0.05），and the female patient group had lower levels of HCY （mmol/L），CREA （mmol/L）， uric acid （mmol/L） and eGFRm than in the male group （all P < 0.05）. The incidence of non-ST-segment elevation myocardial infarction was 47.4% higher than that of the male group （P < 0.05）. Conclusion　 Female patients with acute myocardial infarction have an older age of onset，higher serum GLU and BNP levels. The incidence of non-ST segment elevation myocardial infarction is higher in the female group and higher endoplasmic reticulum stress protein XBP-1S level within 24 hours of onset；while the serum levels of HCY，CREA，uric acid，and eGFRm in male patients with acute myocardial infarction were higher than those in the female group. [ABSTRACT FROM AUTHOR]

Objective To observe the changes of ANP levels in the peripheral blood of patients with essential hypertension in Yunnan, and to explore the relationship between it and the pathogenesis of essential hypertension. Methods We selected 44 patients with essential hypertension diagnosed in the cardiology department of our hospital from June to September 2019 and set them as the case group. We also selected 44 healthy patients from the physical examination center of our hospital as the healthy control group. The ELISA method was used to detect the ANP level in the peripheral blood of the subjects. Results The level of ANP in the peripheral blood of patients with essential hypertension was significantly lower than that of normal people ( P < 0.05)；the occurrence of hypertension was used as the dependent variable and the serum ANP was used as the independent variable for logistic regression analysis. The results showed that ANP The partial regression coefficient with hypertension was 0.071, and the P value was 0.002 (P < 0.05). It was statistically significant; the person correlation analysis was used to analyze ANP and SBP/DBP, and the results showed that the correlation coefficient between ANP and SBP was -0.374. The P value is 0.000 (P < 0.05)；the correlation coefficient between ANP and DBP is - 0.331, and the P value is 0.002（P < 0.05), both of which are statistically significant, but compared to DBP, the correlation between ANP and SBP is more significant. Conclusions The low concentration of ANP in peripheral blood is closely related to the increase of blood pressure; NPR-C ligand ANP is involved in the pathogenesis of essential hypertension; ANP affects the changes in the level of SBP/DBP, and has a more significant impact on SBP. [ABSTRACT FROM AUTHOR]