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Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the oral and maxillofacial region with high incidence and poor prognosis. Cancer cells change their metabolism through glycolytic metabolic reprogramming to support their increased demand for ATP. Glycolytic reprogramming mediates the development of multisystem tumors, including oral squamous cell carcinoma, involving multiple signaling pathways and key factors. In this paper, the changes of glycolytic metabolism, key factors and potential clinical diagnostic and theraputic approches of OSCC are summarized, and the role of OSCC in oral squamous cell carcinoma is reviewed in order to provide new research directions and ideas. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective　To explore the influence and relationship of prepregnancy weight and pregnancy weight gain on pregnancy complications and adverse pregnancy outcomes， and to provide the evidence for the pregnancy health care， reducing pregnancy complications and improving maternal and infant outcomes. Methods　According to the retrospective study method，603 singleton live pregnancies who were hospitalized and delivered in People’s Hospital of Xishuangbanna Dai Autonomous Prefecture with gestational diabetes mellitus （GDM）, hypertension and other diseases and fetal macrosomia during January 2020 to January 2022 were collected. According to the prepregnancy body mass index （BMI） and gestational weight gain （GWG） criteria，they were divided into the low weight group （ n = 31）, normal weight group （ n = 365）, super weight group （ n = 146）, obesity group （n = 61）, underweight gain group （n = 163）, normal weight gain group （n = 230） and excessive weight gain group （n = 210）：The pregnancy complications and adverse pregnancy outcomes，such as cesarean section rate，shoulder dystocia，birth rate of macrosomia，low birth weight infants，and admission rate to NICU were compared and analyzed. Results　Prepregnancy maternal obesity was the influencing factor of preeclampsia. The incidence of preeclampsia，cesarean section，preterm delivery，low birth weight and NICU transfer increased with the increase of BMI before the pregnancy，and the difference was statistically significant （ P < 0.05） . The incidence of macrosomia， shoulder dystocia， preeclampsia and cesarean section increased with the increase of GWG，and the difference was statistically significant （P < 0.05）. Conclusion　High BMI before the pregnancy and excessive weight gain during the pregnancy can increase the incidence of pregnancy complications and lead to the increase in the incidence of adverse pregnancy outcomes. We should further strengthen the management and education of pregnant women’s weight during the pregnancy，and carry out whole-process intervention on weight during the pregnancy. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective The aim of this study was to investigate the application of low molecular weight heparin combined with alteplase for thrombolysis in patients with acute myocardial infarction（AMI），and to compare its thrombolysis effect with traditional anticoagulant-general heparin. Methods 35 AMI patients with alteplase intravenous thrombolytic therapy were divided into two groups，among which 15 cases in the study group were treated with 30 mg enoxaparin instant intravenous injection before thrombolysis，40 mg enoxaparin hypodermic injection 15 minutes after thrombolysis，40 mg enoxaparin hypodermic injection every 12 hours for 5 days. The other 20 cases were assigned to the control group and treated with 4 000 u（or 60 u/kg）general heparin instant intravenous injection，then pumped general heparin intravenously in the rate of 800-1 000 u/h. Meanwhile， detected coagulation convention every 3 hours and adjusted the dose of heparin according to the activated partial thromboplastin time（APTT）to keep APTT value within 1.5 to 2.0 times （50-70 s） the standard value. 48 hours later， patients in the control group was given hypodermic injection of 40 mg enoxaparin every 12 hours for 5 days. All cases were given regular treatment as guidelines recommended. Results The patency rate of infarct-related coronary artery assessed by unified clinical criteria was 86.66% and 65.00%， and the average recanalization time was（1.62±0.36）h and （1.81±0.33）h in the study and control groups， respectively. There were no significant differences on patency rate and recanalization time between the two groups（P > 0.05）. One case of bleeding complication occurred in the study group（6.66%），while five cases occurred in the control group（25.00%）. In the two groups，no cases appeared intracranial hemorrhage and other serious or fatal bleeding occurred. Conclusion The clinical efficacy of low molecular weight heparin was non-inferior to general heparin in AMI patients with alteplas thrombolysis. The application of low molecular weight heparin was simple and easy to operate. It can optimize the procedure of thrombolysis，reduce repetitive coagulation index monitoring and lessen clinical workload，which is worth being promoted to primary hospital and the emergency systems. [ABSTRACT FROM AUTHOR]