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Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate effect of body position on ultrasonographic measurement of ligamentum flavum length in lumbar intervertebral space in the elderly patients. Methods 40 patients over 65 years of age who underwent spinal anesthesia were selected to examine the L3/4, L4/5 and L5 / S1 intervertebral spaces. Anterioredge length of the ligamentum flavum (ALL) and distance from skin to the ligamentum flavum (DSL) of L3/4, L4/5 and L5/S1 intervertebral spaces were measured by ultrasonic parasagittal oblique view in both sitting and left lateral decubitus position, and definition degree of each ultrasonic image were analyzed. Results Compared with the measurement in left lateral position, ALL at L5/S1 level in sitting position was longer, and longer than that at L3/4 in the same position (P < 0.05)；DSL at L5/S1 was lower than that at L3/4 in sitting position (P < 0.05). Compared with ultrasonic definition of L5/S1, the fine definition rate of the left and right sides of L3/4 and L4/5 in both positions was lower (P < 0.05). Conclusion The ALL ultrasonic measurement at L5/S1 level in sitting position was longer than that in left lateral decubitus position, and also longer than that at L3/4 and L4/5 in the same position, its depth and image were shallower and clearer than other spaces. It is recommended for elderly patients to use the paramidian puncture approach for lumbar anesthesia. The relatively shallow width of L5/ S1 should be selected under the sitting position, and the left and right sides are equivalent, especially under the guidance of ultrasound. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To build animal model of hyperhomocysteinemia （HHcy）， and to investigate the expression of TRB3 in adipose tissue and explore the effect of PI3K/Akt signaling pathway by TRB3．Methods Twenty mice were divided into the fasting control group （n = 10） and the fasting HHcy group （n = 10） . Normal food was fed in the fasting control group. Normal food and 1.5% （mass fraction） methionine were fed in the fasting HHcy group.After the mice in every group were fed for three months.Adipose tissue in two groups was The mRNA expressions of TRB3， Akt and glucose transporter 4 （GLUT4） were detected by reverse transcription PCR.The protein expression of TRB3，Akt ， p- Akt （473） and GLUT4 were measured by Western blot. Re s ults The mRNA expression of TRB3 in the fast HHcy group was increasedas compared with the control group. The mRNA expression of Akt and GLUT4 was decreased， however the result had no significant difference between two groups. Compared with the control group， the protein expression of TRB3 was increased and the protein expression of p- Akt （473） was reduced in the fast HHcy group. Whereas the protein expression of Akt and GLUT4 had no significant diffenence between two groups. Conclusion Homocysteine may incease the uptake and utilization of glucose in adipose tissue by inhibiting PI3K/Akt signaling pathway， which may be the results of inducing the expression of TRB3 and downregulating the protein expression of p- Akt （473） and GLUT4. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To evalute the effects of intraoperative dexmedetomidine in adult patients during recovery periods from general anesthesia after lobectomy. Methods Fifty adult patients undergoing lobectomy were randomized into two groups: control group （Group A，n＝25） and dexmedetomidine group （Group B，n＝25） . No differences in baseline characteristics were observed between the groups. All patients were given propofol and remifentanil for anesthetic induction and maintenance. Ten minutes before the anestheia， patients were given dexmedetomidine （1 μg/kg over 10 minutes followed by a continuous infusion of 0.3 μg/kg/h throughout surgery until 10 minutes before the end of operation） or comparable volumes of saline as a placebo. After the surgery, all patients were sent to the post-anesthetic care unit （PACU） with intubation. The parameters including mean arterial pressure （MAP），heart rate （HR），arterial oxygen pressure （PaO2），bispectral index （BIS），respiratory rate （f），tidal volume （TV），sedation-agitation score （SAS），recovery time，and the stay of PACU were recorded. The times of requiring fentanyl and the VAS score were recorded too．Results （1） The MAP and HR in the group B was significantly lower in group B than that in group A （P<0.05） . （2） The BIS and f in the group B was significantly lower in group B than that in group A （P<0.05）， and the TV and PaO2 in group B was significantly higher than that in group A （P<0.05） （3） The SAS score decreased in the group B compared with the group A （P<0.05）.（4） The VAS score was significantly lower in group B than that in group A （P<0.05）， and in the group B， less patients needed fentanyl after extubation （P<0.05）. Conclusions Intraoperative dexmedetomidine administration can significantly reduce the blood pressure and heart rate in patients undergoing thoracic surgery， improve ventilation during recovery, and decrease the occurrence of agitation and postoperative analgesia during analepsia. [ABSTRACT FROM AUTHOR]

Objective To evaluate the safety and efficacy of dexmedetomidine in adult patients during thoractomy under general anesthesia. Methods Seventy-five adult patients undergoing thoractomy were randomized into two groups ： control group (Group A, n = 36) and dexmedetomidine group (Group B, n = 39). No differences in baseline characteristics were observed between the two groups. All patients received propofol and remifentanil for anesthetic induction and maintenance. Patients were given dexmedetomidine ( 1 μg/kg over 10 minutes followed by a continuous infusion of 0.3 μg/ kg/ h throughout surgery) or comparable volumes of saline as a placebo. The parameters including mean arterial pressure (MAP)，heart rate (HR)，bispectral index (BIS)， sedation-agitation scale (SAS), arterial oxygen pressure (PaO2), arterial oxygen saturation (SaO2) and the stay of post-anesthetic care unit (PACU) were recorded. The doses of propofol, remifentanil, atropine and phenylephrine were recorded too. Results Significantly lower MAP and HR were observed over time in the group B compared with the group A (P < 0.05, 0.01). Patients given dexmedetomidine required less propofol for anesthetic induction and maintenance ( P < 0.05) while required higher dosage of phenylephrine ( P < 0.05) during anesthesia. The SAS scores decreased in the group B (P < 0.05) compared with the group A. Significantly higher PaO2 were observed in the group B than in the group A (P < 0.05 ). Conclusions Dexmedetomidine administration can significantly reduce the requirement for propofol during anesthesia, decrease blood pressure and heart rate in patients undergoing thoractomy, and decrease the occurrence of agitation during analepsia, and also imporve the respiration. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)