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Objective To find the relationship between genetic mutation of RAS-MAPK system and non-syndromic congenital heart disease. Methods This study chose 223 cases of non-syndromic congenital heart diseases and 273 cases of healthy people as study objects, and analyzed correlation among three genes（MAP2K2， BRAF，RAF1） which belong to RAS-MAPK system and 22 TagSNPs of TBX20 which were found in syndromic congenital heart disease families. Results Those TagSNPs are unlikely to have relevance to non-syndromic congenital heart diseases （ ＞0.05） . Conclusion The morbigenous genetic mutations found in familial diseases are not likely to be the main factors of the occurrence of non-syndromic congenital heart diseases. [ABSTRACT FROM AUTHOR]