1. 抗 dsDNA 抗体、补体 C3 及其他实验室指标对于诊断 系统性红斑狼疮肾损伤的临床意义.
- Author
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娄 雪, 廖 莉, 赵若彤, 王湘宇, 杨一帆, 刘 爽, and 徐 健
- Abstract
Objective To investigate the clinical application value of anti-dsDNA antibody, complement C3 and other laboratory indicators in patients with systemic lupus erythematosus (SLE) with renal injury. Methods The clinical data of 296 SLE patients were retrospectively analyzed. The differences of autoantibodies and other laboratory indicators between SLE with renal injury group and without renal injury group were compared, and the immunological indicators of SLE renal injury were found. Results The positive rates of serum anti-dsDNA, anti-nucleosome and anti-histone antibodies in SLE with renal injury group were significantly higher than those in without renal injury group, serum renal function indexes such as urea, creatinine and uric acid, electrolytes such as potassium, chlorine and calcium ion were significantly higher than those in without renal injury group, and the levels of immunoglobulin IgG, IgA and complement C3 were significantly lower than those in without renal injury group (P < 0.05). Conclusion Anti-dsDNA, anti-nucleosome, anti-histone autoantibodies, complement C3 and other laboratory indicators may be associated with renal injury in SLE patients. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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