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Objective　To assess the correlation between neutrophil-lymphocyte ratio （NLR） and the disease activity of systemic lupus erythematosus （SLE）. Methods　A total of 536 patients with SLE from the Department of Rheumatology and Immunology of the First Affiliated Hospital of Kunming Medical University were selected. According to the SLE Disease Activity Index （SLEDAI） score，patients with SLE were divided into inactive group，lightly active group，moderately active group，and severely active group. The differences in NLR among the four groups were compared，and the correlation between NLR and SLEDAI score was analyzed through Spearman correlation analysis. Results　There were differences in NLR levels among the four groups. The results of pairwise comparison showed that the NLR level of the moderately active group was higher than that of the inactive group （adjusted P < 0.001）；the NLR level of the severely active group was higher than that of the inactive group （adjusted P < 0.001）；the NLR level of the severely active group was higher than that of the lightly active group （ P = 0.011 after adjustment）. The NLR of SLE patients were positively correlated with SLEDAI scores （ P < 0.05. Conclusion　NLR can be used as a reference index to evaluate the disease activity of SLE patients. [ABSTRACT FROM AUTHOR]

Objective To evaluate the association between neutrophil-lymphocyte ratio （NLR） and renal damage in patients with systemic lupus erythematosus （SLE）. Methods A total of 410 patients with SLE from the Department of Rheumatology and Immunology of the First Affiliated Hospital of Kunming Medical University were selected. According to whether accompanied by renal involvement, patients with SLE were divided into non-lupus nephritis group （non-LN group） and lupus nephritis group （LN group）. The differences in NLR between the two groups were compared, and the correlation between NLR and renal damage was analyzed. Results The NLR of LN group was significantly higher than that of SLE patients in non-LN group, and the difference wsa statistically significant （P < 0.05）. The NLR of SLE patients were positively correlated with leukocyte count, neutrophils count, serum creatinine, blood urea nitrogen, ESR, CRP, PCT and 24-hour urine protein, and negatively correlated with lymphocyte count, total protein, albumin and globulin, respectively. Conclusion NLR can be used as an auxiliary index to evaluate renal damage in SLE patients. [ABSTRACT FROM AUTHOR]

Objective　 To investigate the clinical application value of anti-dsDNA antibody, complement C3 and other laboratory indicators in patients with systemic lupus erythematosus (SLE) with renal injury. Methods　The clinical data of 296 SLE patients were retrospectively analyzed. The differences of autoantibodies and other laboratory indicators between SLE with renal injury group and without renal injury group were compared, and the immunological indicators of SLE renal injury were found. Results　The positive rates of serum anti-dsDNA, anti-nucleosome and anti-histone antibodies in SLE with renal injury group were significantly higher than those in without renal injury group, serum renal function indexes such as urea, creatinine and uric acid, electrolytes such as potassium, chlorine and calcium ion were significantly higher than those in without renal injury group, and the levels of immunoglobulin IgG, IgA and complement C3 were significantly lower than those in without renal injury group (P < 0.05). Conclusion　Anti-dsDNA, anti-nucleosome, anti-histone autoantibodies, complement C3 and other laboratory indicators may be associated with renal injury in SLE patients. [ABSTRACT FROM AUTHOR]