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Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the oral and maxillofacial region with high incidence and poor prognosis. Cancer cells change their metabolism through glycolytic metabolic reprogramming to support their increased demand for ATP. Glycolytic reprogramming mediates the development of multisystem tumors, including oral squamous cell carcinoma, involving multiple signaling pathways and key factors. In this paper, the changes of glycolytic metabolism, key factors and potential clinical diagnostic and theraputic approches of OSCC are summarized, and the role of OSCC in oral squamous cell carcinoma is reviewed in order to provide new research directions and ideas. [ABSTRACT FROM AUTHOR]

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Objective　To explore the influence and relationship of prepregnancy weight and pregnancy weight gain on pregnancy complications and adverse pregnancy outcomes， and to provide the evidence for the pregnancy health care， reducing pregnancy complications and improving maternal and infant outcomes. Methods　According to the retrospective study method，603 singleton live pregnancies who were hospitalized and delivered in People’s Hospital of Xishuangbanna Dai Autonomous Prefecture with gestational diabetes mellitus （GDM）, hypertension and other diseases and fetal macrosomia during January 2020 to January 2022 were collected. According to the prepregnancy body mass index （BMI） and gestational weight gain （GWG） criteria，they were divided into the low weight group （ n = 31）, normal weight group （ n = 365）, super weight group （ n = 146）, obesity group （n = 61）, underweight gain group （n = 163）, normal weight gain group （n = 230） and excessive weight gain group （n = 210）：The pregnancy complications and adverse pregnancy outcomes，such as cesarean section rate，shoulder dystocia，birth rate of macrosomia，low birth weight infants，and admission rate to NICU were compared and analyzed. Results　Prepregnancy maternal obesity was the influencing factor of preeclampsia. The incidence of preeclampsia，cesarean section，preterm delivery，low birth weight and NICU transfer increased with the increase of BMI before the pregnancy，and the difference was statistically significant （ P < 0.05） . The incidence of macrosomia， shoulder dystocia， preeclampsia and cesarean section increased with the increase of GWG，and the difference was statistically significant （P < 0.05）. Conclusion　High BMI before the pregnancy and excessive weight gain during the pregnancy can increase the incidence of pregnancy complications and lead to the increase in the incidence of adverse pregnancy outcomes. We should further strengthen the management and education of pregnant women’s weight during the pregnancy，and carry out whole-process intervention on weight during the pregnancy. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)