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Objective The purpose of this study was to investigate the correlation of serum oxidative stress with MMPs in rheumatoid patients with carotid atherosclerosis. Methods Ninety-two cases of rheumatoid patients were divided into non-carotid atherosclerosis group (group A, 45 cases) and carotid artery (group B,47 cases),while 40 cases of healthy person were selected as the control group (group C) . MMP-3, MMP-9, TIMP-1, MDA, SOD and GSH were detected. Results There were significant differences in MMP-9 and TIMP-1 between groupsA and C(P < 0.05),and in MMP-3,MMP-9 and TIMP-1 between group B and the other two groups (P < 0.05) . Compared with group C,SOD and GSH in group A have decreased significantly(P < 0.05) . There were significant differences in SOD and GSH between group B and groups A and C,and MDA in group B increased significantly compared with group A(P < 0.05) . SOD showed significant correlations with MMP-9 and TIMP-1(P < 0.05), while no correlation with MMP-3 (P > 0.05) . There were negative correlations of GSH with MMP-3 and MMP-9(P < 0.05),while was significant positive correlation with TIMP-1(P < 0.05) . Conclusion MMPs were closely related to the oxidative stress disorder in rheumatoid patients with carotid atherosclerosis, which promote the incidence of carotid artery atherosclerosis. [ABSTRACT FROM AUTHOR]

Objective To investigate the correlation between carotid atherosclerosis and inflammatory factors in patients with rheumatoid and its clinical significance. Methods 92 patients with rheumatoid were divided into non- carotid atherosclerosis group (group A 45 cases), and carotid artery (group B 47 cases), while 40 cases of healthy people were selected as a control group ( group C) . Serum levels of TNF- a, IL-17, CRP, IMT and ICAM-1, VCAM-1 were detected. Results Serum levels of TNF-α, IL-17 of patients in A group were significantly higher than those in group C (P< 0.05), Serum levels of TNF-α, IL-17, CRP of of patients in group B were significantly different to group A and group C (P < 0.05). Serum levels of IMT, ICAM-1, VCAM-1 of A group were significantly higher than those in group C (P< 0.05), Serum levels of IMT, ICAM-1, VCAM-1 of group B were significantly higher than those in group A and group C (P<0.05) . Serum levels of TNF-α and IMT, ICAM-1, VCAM-1 showed a significant positive correlation (P<0.05), Serum levels of IL-17 and ICAM-1, VCAM-1 showed significant positive correlation (P< 0.05), Serum levels of CRP and IMT, ICAM-1, VCAM-1 showed no significant correlation (P>0.05). Conclusion Inflammatory cytokines and carotid atherosclerosis are closely related, and synergically promote the incidence of carotid artery atherosclerosis. [ABSTRACT FROM AUTHOR]