1. Pre-Initiation Effect of Oleuropein towards Apoptotic and Oxidative Stress Levels on the Early Development of Two-Stage Skin Carcinogenesis.
- Author
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Suzliana John, Dayang Noor, Tengku Mamat, Tengku Hasmira, Surien, Omchit, Taib, Izatus Shima, and Masre, Siti Fathiah
- Subjects
OXIDATIVE stress ,CARCINOGENESIS ,SUPEROXIDES ,SKIN ,PHENOLS - Abstract
Background: Oleuropein is a form of phenolic compound which can be majorly found in the olive leaves. Previous studies have shown several biological functions of oleuropein against different cancer cells. Aim and Objectives: This research was designed to study the pre-initiation effect of oleuropein on the early skin tumour development using a mouse model. Material and Methods: Female Institute of Cancer Research (ICR) mice (n=6 per group) were divided into 2 groups (group 1 as a carcinogen control and group 2 as a vehicle control) and 1 treatment group (group 3: 10 mg/kg of oleuropein). Results: After 10 weeks, Group 3 showed delay in epidermal hyperplasia formation and a significant reduction (p<0.05) in the epidermal thickness as compared to Group 1. Data were also displayed a significant increase (p<0.05) in the apoptotic rate in Group 3 as compared to Group 1 and 2. For biochemical assays, the level of Malondialdehyde (MDA) was significantly (p<0.05) decreased whilst the levels of Glutathione (GSH) and Superoxide Dismutase (SOD) were significantly (p<0.05) increased in Group 3 as compared to Group 1. Conclusion: Our results indicate that pre-initiation treatment of oleuropein may prevent skin tumour development through its antioxidant and apoptotic activities. [ABSTRACT FROM AUTHOR]
- Published
- 2019