1. Akciğer Kanserli Hastalarda Radyasyona Bağlı Özefajit ve Kilo Kaybının Önlenmesinde Oral Glutaminin Etkisi.
- Author
-
KARABULUT GÜL, Şule, ORUÇ, Ahmet Fatih, ATALAY, Ramazan, YAVUZ, Berrin Benli, GEDİK, Duygu, and AKSU, Atınç
- Abstract
Background: At this study, the effect of oral glutamine usage in the prevention of acute esphagitis and weight loss in lung cancer patients receiving radiotherapy (RT) was evaluated. Methods: The study included 88 patients. Results were evaluated retrospectively. Glutamine dose was 30 g daily (10 g/8 hours) during thoracic RT and for 2 weeks after RT. Once-daily 1.8-2Gy RT with one fraction was used, and 60-64 Gy RT was performed with 5 fractions of weekly treatment. Patients' weight, body mass index (BMI) and esophagitis levels were evaluated weekly. Results: Glutamine was well tolerated by all the patients. Mean esophagus RT doses were 15.56 (12-26) Gy. No dysphagia was observed in 35 patients (39.8%), but 53 (60.2%) were found to have dysphagia. Grade 3 and Grade 4 dysphagia was not observed. Weight loss was not observed in 17 (19.3%) patients. Weight loss was observed in 20 (22.7%) patients, while weight gain was observed in 51 (58%) patients. In 19 (95%) of 20 patients with weight loss, dysphagia was present. In 34 of 68 patients who didn't have weight loss, dysphagia was present (p=0.001). Esophagitis was detected less in the patient groups that received no more than esophagus dose of 20 Gy, with peripheral localized tumors, and patient groups that received 4 or fewer chemotherapy treatments (p=0.002). Conclusion: Oral glutamine usage is decreasing the severity and frequency of esophagitis in patients receiving RT for lung cancer and is helpful for the prevention of weight loss. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF