1. The Acute Toxicity and Pharmacokinetics of the BSH
- Author
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LI Feng-lin, LUO Zhi-fu, FAN Cai-yun, LIU Zi-hua, and DENG Xin-rong
- Subjects
lcsh:QC770-798 ,lcsh:Nuclear and particle physics. Atomic energy. Radioactivity ,BNCT BSH acute toxicity pharmacokinetics biodistribution - Abstract
In this study, the acute toxicity of BSH was studied at doses of 210, 300, 430, 614 mg/kg, and the LD50 was calculated at 381.94 mg/kg. A three-compartment model system was used to evaluate the pharmacokinetics of the BSH, and the pharmacokinetic parameters, such as t1/2，Vd, AUC, CL of BSH were calculated: t1/2α=3.6 min, t1/2β=55.8 min, t1/2γ=6.26 h, Vd=3 523.58 mL/kg, AUC= 247.55 hr*μg/mL, CL=3572.45 mL/hr/kg. The biodistribution of the BSH was studied in normal mice, from which the characteristics of biodistribution of BSH was analyzed.
- Published
- 2016
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