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Your search keyword '"Varga, Georg"' showing total 5 results
Start Over Author "Varga, Georg" Journal journal of investigative dermatology
5 results on '"Varga, Georg"'

3. Functional Characterization and Expression Analysis of the Proteinase-Activated Receptor-2 in Human Cutaneous Mast Cells

Author

Moormann, Corinna, primary, Artuc, Metin, additional, Pohl, Elena, additional, Varga, Georg, additional, Buddenkotte, Jörg, additional, Vergnolle, Nathalie, additional, Brehler, Randolf, additional, Henz, Beate M., additional, Schneider, Stefan W., additional, Luger, Thomas A., additional, and Steinhoff, Martin, additional

Published
2006
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4. DermaVir: A Novel Topical Vaccine for HIV/AIDS

Author

Lisziewicz, Julianna, primary, Trocio, Jeffrey, additional, Whitman, Lucia, additional, Varga, Georg, additional, Xu, Jianqing, additional, Bakare, Nyasha, additional, Erbacher, Patrick, additional, Fox, Cecil, additional, Woodward, Ruth, additional, Markham, Phil, additional, Arya, Suresh, additional, Behr, Jean-Paul, additional, and Lori, Franco, additional

Published
2005
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5. LFA-1 Contributes to Signal I of T-Cell Activation and to the Production of Th1 Cytokines.

Author

Varga, Georg, Nippe, Nadine, Balkow, Sandra, Peters, Thorsten, Wild, Martin K., Seeliger, Stephan, Beissert, Stefan, Krummen, Mathias, Roth, Johannes, Sunderkötter, Cord, and Grabbe, Stephan

Subjects
*T cells, *INTEGRINS, *CELL adhesion molecules, *LEUCOCYTES, *IMMUNOGLOBULINS
Abstract

The β2 integrins are important for both transendothelial migration of leukocytes and T-cell activation during antigen presentation. In T cells, triggering of leukocyte functional antigen-1 (LFA-1) is required for full activation and T-helper (Th)1/Th2 differentiation. We used CD18-deficient (CD18−/−) mice to examine the role of LFA-1 in the activation of T cells. Compared with wild-type controls, CD18−/− T cells proliferated normally when stimulated with antibodies against CD3 and CD28, but secreted significantly less IFN-γ and IL-2 than their wild-type counterparts. However, when T cells were stimulated with dendritic cells (DCs) that provide additional LFA-1 ligation, the proliferation of CD18−/− T cells was significantly reduced, whereas cytokine production remained impaired. The diminished proliferative capacity of CD18−/− T cells could be fully compensated for by additional triggering of the T-cell receptor, but not by additional stimulation through the costimulatory molecule, CD28. Thus, ligation of LFA-1 on T cells participates in regulation of Th1 cytokines in vivo. In addition, LFA-1 primarily exerts an effect as an enhancer of TCR signalling and does not facilitate classical costimulation. [ABSTRACT FROM AUTHOR]

Published
2010
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