Search

Your search keyword '"Simpson, Eric"' showing total 14 results
Start Over Author "Simpson, Eric" Journal journal of investigative dermatology
14 results on '"Simpson, Eric"'

2. A Randomized Placebo-Controlled Trial of Secukinumab on Aortic Vascular Inflammation in Moderate-to-Severe Plaque Psoriasis (VIP-S)

Author

Gelfand, Joel M., Shin, Daniel B., Duffin, Kristina Callis, Armstrong, April W., Blauvelt, Andrew, Tyring, Stephen K., Menter, Alan, Gottlieb, Scott, Lockshin, Benjamin N., Simpson, Eric L., Kianifard, Farid, Sarkar, Rajendra Prasad, Muscianisi, Elisa, Steadman, Jennifer, Ahlman, Mark A., Playford, Martin P., Joshi, Aditya A., Dey, Amit K., Werner, Thomas J., Alavi, Abass, and Mehta, Nehal N.

Published
2020
Full Text
View/download PDF

9. Patients with Atopic Dermatitis Colonized with Staphylococcus aureusHave a Distinct Phenotype and Endotype

Author

Simpson, Eric L., Villarreal, Miguel, Jepson, Brett, Rafaels, Nick, David, Gloria, Hanifin, Jon, Taylor, Patricia, Boguniewicz, Mark, Yoshida, Takeshi, De Benedetto, Anna, Barnes, Kathleen C., Leung, Donald Y.M., and Beck, Lisa A.

Abstract

Patients with atopic dermatitis (AD) are commonly colonized with Staphylococcus aureus(AD S. aureus+), but what differentiates this group from noncolonized AD patients (AD S. aureus–) has not been well studied. To evaluate whether these two groups have unique phenotypic or endotypic features, we performed a multicenter, cross-sectional study enrolling AD S. aureus+(n = 51) and AD S. aureus–(n = 45) participants defined by the presence or absence of S. aureusby routine culture techniques and nonatopic, noncolonized control individuals (NA S. aureus–) (n = 46). Filaggrin (FLG) genotypes were determined, and disease severity (Eczema Area and Severity Index, Rajka-Langeland Severity Score, Investigator’s Global Assessment score, Numerical Rating Scale, and Dermatology Life Quality Index) was captured. Skin physiology was assessed (transepidermal water loss [TEWL], stratum corneum integrity, hydration, and pH), and serum biomarkers were also measured. We found that AD S. aureus+patients had more severe disease based on all scoring systems except itch (Numerical Rating Scale), and they had higher levels of type 2 biomarkers (eosinophil count, tIgE, CCL17, and periostin). Additionally, AD S. aureus+patients had significantly greater allergen sensitization (Phadiatop and tIgE), barrier dysfunction (TEWL and stratum corneum integrity), and serum lactate dehydrogenase (LDH) than both the AD S. aureus–and NA S. aureus–groups. FLGmutations did not associate with S. aureus+colonization. In conclusion, adult patients with AD who are colonized on their skin with S. aureushave more severe disease, greater type 2 immune deviation, allergen sensitization, barrier disruption, and LDH level elevation than noncolonized patients with AD.

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results