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Your search keyword '"Schneider, Stefan W."' showing total 8 results
Start Over Author "Schneider, Stefan W." Journal journal of investigative dermatology
8 results on '"Schneider, Stefan W."'

1. Pathogenic Activation and Therapeutic Blockage of FcαR-Expressing Polymorphonuclear Leukocytes in IgA Pemphigus

Author

Emtenani, Shirin, Ghorbanalipoor, Saeedeh, Mayer-Hain, Sarah, Kridin, Khalaf, Komorowski, Lars, Probst, Christian, Hashimoto, Takashi, Pas, Hendri H., Męcińska-Jundziłł, Kaja, Czajkowski, Rafał, Recke, Andreas, Sunderkötter, Cord, Schneider, Stefan W., Hundt, Jennifer E., Zillikens, Detlef, Schmidt, Enno, Ludwig, Ralf J., and Hammers, Christoph M.

Published
2021
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4. Coculture Model of Sensory Neurites and Keratinocytes to Investigate Functional Interaction: Chemical Stimulation and Atomic Force Microscope–Transmitted Mechanical Stimulation Combined with Live-Cell Imaging

Author

Klusch, Andreas, primary, Ponce, Leslie, additional, Gorzelanny, Christian, additional, Schäfer, Ina, additional, Schneider, Stefan W., additional, Ringkamp, Matthias, additional, Holloschi, Andreas, additional, Schmelz, Martin, additional, Hafner, Mathias, additional, and Petersen, Marlen, additional

Published
2013
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7. Functional Characterization and Expression Analysis of the Proteinase-Activated Receptor-2 in Human Cutaneous Mast Cells

Author

Moormann, Corinna, primary, Artuc, Metin, additional, Pohl, Elena, additional, Varga, Georg, additional, Buddenkotte, Jörg, additional, Vergnolle, Nathalie, additional, Brehler, Randolf, additional, Henz, Beate M., additional, Schneider, Stefan W., additional, Luger, Thomas A., additional, and Steinhoff, Martin, additional

Published
2006
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8. Pathogenic Activation and Therapeutic Blockage of Fc Alpha Receptor-Expressing Polymorphonuclear Leukocytes in IgA Pemphigus

Author

Emtenani, Shirin, Ghorbanalipoor, Saeedeh, Mayer-Hain, Sarah, Kridin, Khalaf, Komorowski, Lars, Probst, Christian, Hashimoto, Takashi, Pas, Hendri H., Męcińska-Jundziłł, Kaja, Czajkowski, Rafał, Recke, Andreas, Sunderkötter, Cord, Schneider, Stefan W., Hundt, Jennifer E., Zillikens, Detlef, Schmidt, Enno, Ludwig, Ralf J., and Hammers, Christoph M.

Abstract

Pathomechanisms in IgA pemphigus are assumed to rely on Fc-dependent cellular activation by antigen-specific IgA autoantibodies, however, models for disease and more detailed pathophysiologic data are lacking. We here aimed to establish in vitromodels of disease for IgA pemphigus, allowing to study effects of the interaction of anti-keratinocyte IgA with cell-surface Fc alpha receptors. Employing multiple in vitroassays, such as a skin cryosection assay and a human skin organ culture model, we here present mechanistic data for the pathogenesis of IgA pemphigus, mediated by anti-desmoglein 3 IgA autoantibodies. Our results reveal that this disease is dependent on Fc alpha receptor-mediated activation of leukocytes in the epidermis. Importantly, this cell-dependent pathology can be dose-dependently abrogated by peptide-mediated inhibition of Fc alpha receptor:IgA interaction, as confirmed in an additional model for IgA-dependent disease, i.e., IgA vasculitis. These data suggest that IgA pemphigus can be modeled in vitro, and IgA pemphigus and IgA vasculitis are Fc alpha receptor-dependent disease entities that can be specifically targeted in these experimental systems.

Published
2021
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