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Start Over Author "Mann, Graham" Journal journal of investigative dermatology
16 results on '"Mann, Graham"'

2. Molecular Genomic Profiling of Melanocytic Nevi

Author

Colebatch, Andrew J., Ferguson, Peter, Newell, Felicity, Kazakoff, Stephen H., Witkowski, Tom, Dobrovic, Alexander, Johansson, Peter A., Saw, Robyn P.M., Stretch, Jonathan R., McArthur, Grant A., Long, Georgina V., Thompson, John F., Pearson, John V., Mann, Graham J., Hayward, Nicholas K., Waddell, Nicola, Scolyer, Richard A., and Wilmott, James S.

Published
2019
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3. Assessing the Incremental Contribution of Common Genomic Variants to Melanoma Risk Prediction in Two Population-Based Studies

Author

Mann, Graham J., Cust, Anne E., Schmid, Helen, Hopper, John L., Aitken, Joanne F., Armstrong, Bruce K., Giles, Graham G., Holland, Elizabeth, Kefford, Richard F., Jenkins, Mark A., Newton Bishop, Julia A., Affleck, Paul, Barrett, Jennifer H., Bishop, D. Timothy, Harrison, Jane, Iles, Mark M., Randerson-Moor, Juliette, Harland, Mark, Taylor, John C., Whittaker, Linda, Kukalizch, Kairen, Leake, Susan, Karpavicius, Birute, Haynes, Sue, Mack, Tricia, Chan, May, Taylor, Yvonne, Davies, John, King, Paul, Drummond, Martin, Kanetsky, Peter A., Goldstein, Alisa M., MacGregor, Stuart, Law, Matthew H., Bui, Minh, Brossard, Myriam, Demenais, Florence, Hoggart, Clive, Brown, Kevin M., Landi, Maria Teresa, and Newton-Bishop, Julia A.

Published
2018
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4. Germline Variation at CDKN2A and Associations with Nevus Phenotypes among Members of Melanoma Families

Author

Taylor, Nicholas J., Mitra, Nandita, Goldstein, Alisa M., Tucker, Margaret A., Avril, Marie-Françoise, Azizi, Esther, Bergman, Wilma, Bishop, D. Timothy, Bressac-de Paillerets, Brigitte, Bruno, William, Calista, Donato, Cannon-Albright, Lisa A., Cuellar, Francisco, Cust, Anne E., Demenais, Florence, Elder, David E., Gerdes, Anne-Marie, Ghiorzo, Paola, Grazziotin, Thais C., Hansson, Johan, Harland, Mark, Hayward, Nicholas K., Hocevar, Marko, Höiom, Veronica, Ingvar, Christian, Landi, Maria Teresa, Landman, Gilles, Larre-Borges, Alejandra, Leachman, Sancy A., Mann, Graham J., Nagore, Eduardo, Olsson, Håkan, Palmer, Jane M., Perić, Barbara, Pjanova, Dace, Pritchard, Antonia, Puig, Susana, van der Stoep, Nienke, Wadt, Karin A.W., Whitaker, Linda, Yang, Xiaohong R., Newton Bishop, Julia A., Gruis, Nelleke A., and Kanetsky, Peter A.

Published
2017
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5. Assessing the Incremental Contribution of Common Genomic Variants to Melanoma Risk Prediction in Two Population-Based Studies

Author

Cust, Anne E., primary, Drummond, Martin, additional, Kanetsky, Peter A., additional, Goldstein, Alisa M., additional, Barrett, Jennifer H., additional, MacGregor, Stuart, additional, Law, Matthew H., additional, Iles, Mark M., additional, Bui, Minh, additional, Hopper, John L., additional, Brossard, Myriam, additional, Demenais, Florence, additional, Taylor, John C., additional, Hoggart, Clive, additional, Brown, Kevin M., additional, Landi, Maria Teresa, additional, Newton-Bishop, Julia A., additional, Mann, Graham J., additional, Bishop, D. Timothy, additional, Cust, Anne E., additional, Schmid, Helen, additional, Aitken, Joanne F., additional, Armstrong, Bruce K., additional, Giles, Graham G., additional, Holland, Elizabeth, additional, Kefford, Richard F., additional, Jenkins, Mark A., additional, Newton Bishop, Julia A., additional, Affleck, Paul, additional, Harrison, Jane, additional, Randerson-Moor, Juliette, additional, Harland, Mark, additional, Whittaker, Linda, additional, Kukalizch, Kairen, additional, Leake, Susan, additional, Karpavicius, Birute, additional, Haynes, Sue, additional, Mack, Tricia, additional, Chan, May, additional, Taylor, Yvonne, additional, Davies, John, additional, and King, Paul, additional

Published
2018
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6. Phenotypic and Histopathological Tumor Characteristics According to CDKN2A Mutation Status among Affected Members of Melanoma Families

Author

Taylor, Nicholas J., primary, Handorf, Elizabeth A., additional, Mitra, Nandita, additional, Avril, Marie-Françoise, additional, Azizi, Esther, additional, Bergman, Wilma, additional, Bianchi-Scarrà, Giovanna, additional, Bishop, D. Timothy, additional, Bressac-de Paillerets, Brigitte, additional, Calista, Donato, additional, Cannon-Albright, Lisa A., additional, Cuellar, Francisco, additional, Cust, Anne E., additional, Demenais, Florence, additional, Elder, David E., additional, Friedman, Eitan, additional, Gerdes, Anne-Marie, additional, Ghiorzo, Paola, additional, Goldstein, Alisa M., additional, Grazziotin, Thais C., additional, Hansson, Johan, additional, Hayward, Nicholas K., additional, Hocevar, Marko, additional, Höiom, Veronica, additional, Holland, Elizabeth A., additional, Ingvar, Christian, additional, Landi, Maria Teresa, additional, Landman, Gilles, additional, Larre-Borges, Alejandra, additional, Leachman, Sancy A., additional, Mann, Graham J., additional, Nagore, Eduardo, additional, Olsson, Håkan, additional, Palmer, Jane, additional, Perić, Barbara, additional, Pjanova, Dace, additional, Puig, Susana, additional, Schmid, Helen, additional, van der Stoep, Nienke, additional, Tucker, Margaret A., additional, Wadt, Karin A.W., additional, Whitaker, Linda, additional, Yang, Xiaohong R., additional, Newton Bishop, Julia A., additional, Gruis, Nelleke A., additional, and Kanetsky, Peter A., additional

Published
2016
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8. Germline Variation at CDKN2Aand Associations with Nevus Phenotypes among Members of Melanoma Families

Author

Taylor, Nicholas J., Mitra, Nandita, Goldstein, Alisa M., Tucker, Margaret A., Avril, Marie-Françoise, Azizi, Esther, Bergman, Wilma, Bishop, D. Timothy, Bressac-de Paillerets, Brigitte, Bruno, William, Calista, Donato, Cannon-Albright, Lisa A., Cuellar, Francisco, Cust, Anne E., Demenais, Florence, Elder, David E., Gerdes, Anne-Marie, Ghiorzo, Paola, Grazziotin, Thais C., Hansson, Johan, Harland, Mark, Hayward, Nicholas K., Hocevar, Marko, Höiom, Veronica, Ingvar, Christian, Landi, Maria Teresa, Landman, Gilles, Larre-Borges, Alejandra, Leachman, Sancy A., Mann, Graham J., Nagore, Eduardo, Olsson, Håkan, Palmer, Jane M., Perić, Barbara, Pjanova, Dace, Pritchard, Antonia, Puig, Susana, van der Stoep, Nienke, Wadt, Karin A.W., Whitaker, Linda, Yang, Xiaohong R., Newton Bishop, Julia A., Gruis, Nelleke A., and Kanetsky, Peter A.

Abstract

Germline mutations in CDKN2Aare frequently identified among melanoma kindreds and are associated with increased atypical nevus counts. However, a clear relationship between pathogenic CDKN2Amutation carriage and other nevus phenotypes including counts of common acquired nevi has not yet been established. Using data from GenoMEL, we investigated the relationships between CDKN2Amutation carriage and 2-mm, 5-mm, and atypical nevus counts among blood-related members of melanoma families. Compared with individuals without a pathogenic mutation, those who carried one had an overall higher prevalence of atypical (odds ratio = 1.64; 95% confidence interval = 1.18–2.28) nevi but not 2-mm nevi (odds ratio = 1.06; 95% confidence interval = 0.92–1.21) or 5-mm nevi (odds ratio = 1.26; 95% confidence interval = 0.94–1.70). Stratification by case status showed more pronounced positive associations among non-case family members, who were nearly three times (odds ratio = 2.91; 95% confidence interval = 1.75–4.82) as likely to exhibit nevus counts at or above the median in all three nevus categories simultaneously when harboring a pathogenic mutation (vs. not harboring one). Our results support the hypothesis that unidentified nevogenic genes are co-inherited with CDKN2Aand may influence carcinogenesis.

Published
2017
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9. Oncogenic B-RAFV600E Signaling Induces the T-Box3 Transcriptional Repressor to Repress E-Cadherin and Enhance Melanoma Cell Invasion

Author

Boyd, Suzanah C., primary, Mijatov, Branka, additional, Pupo, Gulietta M., additional, Tran, Sieu L., additional, Gowrishankar, Kavitha, additional, Shaw, Heather M., additional, Goding, Colin R., additional, Scolyer, Richard A., additional, Mann, Graham J., additional, Kefford, Richard F., additional, Rizos, Helen, additional, and Becker, Therese M., additional

Published
2013
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10. BRAF Mutation, NRAS Mutation, and the Absence of an Immune-Related Expressed Gene Profile Predict Poor Outcome in Patients with Stage III Melanoma

Author

Mann, Graham J., primary, Pupo, Gulietta M., additional, Campain, Anna E., additional, Carter, Candace D., additional, Schramm, Sarah-Jane, additional, Pianova, Svetlana, additional, Gerega, Sebastien K., additional, De Silva, Chitra, additional, Lai, Kenneth, additional, Wilmott, James S., additional, Synnott, Maria, additional, Hersey, Peter, additional, Kefford, Richard F., additional, Thompson, John F., additional, Yang, Yee Hwa, additional, and Scolyer, Richard A., additional

Published
2013
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14. Phenotypic and Histopathological Tumor Characteristics According to CDKN2AMutation Status among Affected Members of Melanoma Families

Author

Taylor, Nicholas J., Handorf, Elizabeth A., Mitra, Nandita, Avril, Marie-Françoise, Azizi, Esther, Bergman, Wilma, Bianchi-Scarrà, Giovanna, Bishop, D. Timothy, Bressac-de Paillerets, Brigitte, Calista, Donato, Cannon-Albright, Lisa A., Cuellar, Francisco, Cust, Anne E., Demenais, Florence, Elder, David E., Friedman, Eitan, Gerdes, Anne-Marie, Ghiorzo, Paola, Goldstein, Alisa M., Grazziotin, Thais C., Hansson, Johan, Hayward, Nicholas K., Hocevar, Marko, Höiom, Veronica, Holland, Elizabeth A., Ingvar, Christian, Landi, Maria Teresa, Landman, Gilles, Larre-Borges, Alejandra, Leachman, Sancy A., Mann, Graham J., Nagore, Eduardo, Olsson, Håkan, Palmer, Jane, Perić, Barbara, Pjanova, Dace, Puig, Susana, Schmid, Helen, van der Stoep, Nienke, Tucker, Margaret A., Wadt, Karin A.W., Whitaker, Linda, Yang, Xiaohong R., Newton Bishop, Julia A., Gruis, Nelleke A., and Kanetsky, Peter A.

Published
2016
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15. Oncogenic B-RAFV600E Signaling Induces the T-Box3 Transcriptional Repressor to Repress E-Cadherin and Enhance Melanoma Cell Invasion.

Author

Boyd, Suzanah C, Mijatov, Branka, Pupo, Gulietta M, Tran, Sieu L, Gowrishankar, Kavitha, Shaw, Heather M, Goding, Colin R, Scolyer, Richard A, Mann, Graham J, Kefford, Richard F, Rizos, Helen, and Becker, Therese M

Subjects
*CANCER cells, *CELL proliferation, *CADHERINS, *TRANSCRIPTION factors, *CELL adhesion molecules, *GENETIC repressors
Abstract

Approximately 50% of melanomas require oncogenic B-RAFV600E signaling for proliferation, survival, and metastasis, and the use of highly selective B-RAF inhibitors has yielded remarkable, although short-term, clinical responses. Reactivation of signaling downstream of B-RAF is frequently associated with acquired resistance to B-RAF inhibitors, and the identification of B-RAF targets may therefore provide new strategies for managing melanoma. In this report, we applied whole-genome expression analyses to reveal that oncogenic B-RAFV600E regulates genes associated with epithelial-mesenchymal transition in normal cutaneous human melanocytes. Most prominent was the B-RAF-mediated transcriptional repression of E-cadherin, a keratinocyte-melanoma adhesion molecule whose loss is intimately associated with melanoma invasion and metastasis. Here we identify a link between oncogenic B-RAF, the transcriptional repressor Tbx3, and E-cadherin. We show that B-RAFV600E induces the expression of Tbx3, which potently represses E-cadherin expression in melanocytes and melanoma cells. Tbx3 expression is normally restricted to developmental embryonic tissues and promoting cell motility, but it is also aberrantly increased in various cancers and has been linked to tumor cell invasion and metastasis. We propose that this B-RAF/Tbx3/E-cadherin pathway has a critical role in promoting the metastasis of B-RAF-mutant melanomas. [ABSTRACT FROM AUTHOR]

Published
2013
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16. Selective Loss of Wild-Type p16INK4a Expression in Human Nevi.

Author

Scurr, Lyndee L, McKenzie, Heather A, Becker, Therese M, Irvine, Mal, Lai, Ken, Mann, Graham J, Scolyer, Richard A, Kefford, Richard F, and Rizos, Helen

Subjects
*LETTERS to the editor, *GENE expression, *CELL proliferation
Abstract

A letter to the editor is presented in response to the article "Loss of expression of the p16INK4/CDKN2 gene in cutaneous malignant melanoma correlates with tumor cell proliferation and invasive stage," by L. Talve and colleagues in the 1997 issue.

Published
2011
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