1. Loss of HLA-DR Expression by Human Epidermal Cells After Growth in Culture
- Author
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James B. Amberson, David G. Biozes, Marc E. Weksler, and John M. Hefton
- Subjects
T-Lymphocytes ,Immunocytochemistry ,Antigens, Differentiation, Myelomonocytic ,Fluorescent Antibody Technique ,Dermatology ,Biology ,Biochemistry ,Antigen ,Transplantation Immunology ,HLA-DR ,Homologous chromosome ,Humans ,Transplantation, Homologous ,Molecular Biology ,Cells, Cultured ,HLA-DR Antigen ,Skin ,integumentary system ,Histocompatibility Antigens Class II ,HLA-DR Antigens ,Cell Biology ,Molecular biology ,In vitro ,Cell biology ,Transplantation ,Kinetics ,Microscopy, Electron ,Cell culture ,Antigens, Surface ,Epidermis - Abstract
These studies present evidence that when human epidermal cells are grown in culture they lose both the ability to stimulate the proliferation of allogeneic T lymphocytes in vitro and their expression of HLA-DR antigens. Our results also show that epidermal cells incubated with anti-HLA-DR serum lose their ability to stimulate the proliferation to allogeneic T lymphocytes in a mixed skin cell-lymphocyte reaction.
- Published
- 1984
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