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Your search keyword '"Andersen, Mads Hald"' showing total 8 results
Start Over Author "Andersen, Mads Hald" Journal journal of investigative dermatology
8 results on '"Andersen, Mads Hald"'

1. The Expression of IL-21 Is Promoted by MEKK4 in Malignant T Cells and Associated with Increased Progression Risk in Cutaneous T-Cell Lymphoma

Author

Fredholm, Simon, primary, Litvinov, Ivan V., additional, Mongan, Nigel P., additional, Schiele, Sarah, additional, Willerslev-Olsen, Andreas, additional, Petersen, David Leander, additional, Krejsgaard, Thorbjørn, additional, Sibbesen, Nina, additional, Nastasi, Claudia, additional, Bonefeld, Charlotte M., additional, Persson, Jenny L., additional, Straten, Per Thor, additional, Andersen, Mads Hald, additional, Koralov, Sergei B., additional, Wasik, Mariusz M., additional, Geisler, Carsten, additional, Sasseville, Denis, additional, Woetmann, Anders, additional, and Ødum, Niels, additional

Published
2016
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3. Cytotoxic T Cells

Author

Andersen, Mads Hald, primary, Schrama, David, additional, thor Straten, Per, additional, and Becker, Jürgen C., additional

Published
2006
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8. Melanoma inhibitor of apoptosis protein (ML-IAP) specific cytotoxic T lymphocytes cross-react with an epitope from the auto-antigen SS56.

Author

Baek Sørensen R, Faurschou M, Troelsen L, Schrama D, Jacobsen S, Becker JC, Thor Straten P, and Andersen MH

Subjects
Cross Reactions, Epitopes, Flow Cytometry, Humans, Lupus Erythematosus, Systemic immunology, Peptide Fragments immunology, Receptors, Antigen, T-Cell physiology, Sjogren's Syndrome immunology, Tripartite Motif Proteins, Adaptor Proteins, Signal Transducing immunology, Autoantigens immunology, Inhibitor of Apoptosis Proteins immunology, Neoplasm Proteins immunology, T-Lymphocytes, Cytotoxic immunology, Ubiquitin-Protein Ligases immunology
Abstract

A large proportion of melanoma patients host a spontaneous T-cell response specifically against ML-IAP-derived peptides. In this study, we describe that some ML-IAP-specific cytotoxic T cells isolated from melanoma patients cross react with an epitope from the auto-antigen SS56. SS56 is a recently described target of autoantibody responses in Sjögren's syndrome (SS) as well as systemic lupus erythematosus (SLE). Here, we describe that SS56 is also an auto-antigen for T cells in SS and SLE. Hence, SS56-specific T cells could readily be detected in circulation and among the infiltrating cells of SLE skin lesions. SS56-specific T cells were able to lyse target cells presenting the peptide epitope on the surface. Notably, SS56-specific CD8 T cells isolated from an SS patient cross reacted with the ML-IAP epitope. This early evidence of a target for auto-reactive CTL in SS and SLE patients; it is to our knowledge previously unreported and underscores the important role of CD8 T cells in autoimmune disorders. Furthermore, the cross-reactivity against the auto-antigen SS56 and the tumor-antigen ML-IAP confirms the link between autoimmunity and anti-cancer cellular immune responses.

Published
2009
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