1. Low anti‐SARS‐CoV‐2 S antibody levels predict increased mortality and dissemination of viral components in the blood of critical COVID‐19 patients
- Author
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Rubén Herrán-Monge, Wysali Trapiello, Laia Fernández-Barat, Cristina Doncel, Milagros González-Rivera, Carolina Puertas, Marta Domínguez-Gil, Jesus F. Bermejo-Martin, María José Muñoz-Gómez, Elena Bustamante, Felipe Pérez-García, Ana P. Tedim, Pedro Enriquez, Isidoro Martínez, Jesús Rico-Feijoo, David J. Kelvin, Vicente Mas, María Martín-Vicente, Noelia Jorge, P. Olivares, José María Eiros, Raquel Almansa, Mónica Herrero Vázquez, Antoni Torres, Ferran Barbé, Cesar Aldecoa, Anna Motos, José Manuel Gómez, Gloria Renedo, Jose Ángel Berezo, Amanda de la Fuente, Salvador Resino, Alicia Ortega, Nuria Mamolar, Ramón Cicuendez, Juan Bustamante-Munguira, Jamil Antonio Cedeno, Silvia Martín, Luis Tamayo, and Ricard Ferrer
- Subjects
Coronavirus disease 2019 (COVID-19) ,Critical Illness ,viruses ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Antibodies, Viral ,03 medical and health sciences ,0302 clinical medicine ,COVID‐19 ,S Antibody ,antigenaemia ,Internal Medicine ,Humans ,antibodies ,Medicine ,030212 general & internal medicine ,Antigens, Viral ,030304 developmental biology ,0303 health sciences ,Viral Components ,biology ,SARS-CoV-2 ,Critically ill ,business.industry ,Brief Report ,COVID-19 ,mortality ,3. Good health ,Icu admission ,Viral replication ,Immunology ,biology.protein ,RNA, Viral ,RNA ,Brief Reports ,Antibody ,business - Abstract
Background Anti‐SARS‐CoV‐2 S antibodies prevent viral replication. Critically ill COVID‐19 patients show viral material in plasma, associated with a dysregulated host response. If these antibodies influence survival and viral dissemination in ICU‐COVID patients is unknown. Patients/Methods We studied the impact of anti‐SARS‐CoV‐2 S antibodies levels on survival, viral RNA‐load in plasma, and N‐antigenaemia in 92 COVID‐19 patients over ICU admission. Results Frequency of N‐antigenaemia was >2.5‐fold higher in absence of antibodies. Antibodies correlated inversely with viral RNA‐load in plasma, representing a protective factor against mortality (Adjusted HR [CI 95%], p): (S IgM [AUC ≥ 60]: 0.44 [0.22; 0.88], 0.020); (S IgG [AUC ≥ 237]: 0.31 [0.16; 0.61]
- Published
- 2021
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