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With the medical internet of things, many automated diagnostic models related to eye diseases are easier. The doctors could quickly contrast and compare retina fundus images. The retina image contains a lot of information in the image. The task of detecting diabetic macular edema from retinal images in the healthcare system is difficult because the details in these images are very small. This paper proposed the new model based on the medical internet of things for predicting diabetic macular edema in retina fundus images. The method called DMER (Diabetic Macular Edema in Retina fundus images) to detect diabetic macular edema in retina fundus images based on improving deep residual network being combined with feature pyramid network in the context of the medical internet of things. The DMER method includes the following stages: (i) ResNet101 improved combining with feature pyramid network is used to extract features of the image and obtain the map of these features; (ii) a region proposal network to look for potential anomalies; and (iii) the predicted bounding boxes against the true bounding box by the regression method to certify the capability of macular edema. The MESSIDOR and DIARETDB1 datasets are used for testing with evaluation criteria such as sensitivity, specificity, and accuracy. The accuracy of the DMER method is about 98.08% with MESSIDOR dataset and 98.92% with DIARETDB1 dataset. The results of the method DMER are better than those of the other methods up to the present time with the above datasets. [ABSTRACT FROM AUTHOR]