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Yeasts and organic minerals are used in diets to improve health, productive performance and some carcass characteristics of ruminants and non-ruminants. Thirty-two lambs (Pelibuey×Katahdin; BW=(30.55±1.67) kg; n=8) were used in a 56-d feeding experiment to study the effects of different levels of live yeast (Saccharomyces cerevisiae; yeast), selenium (Se) and chromium (Cr) mixed (Se-Cr), and a mixture of yeast-Se-Cr on growth performance and carcass traits. Animals were stratified by body weight (BW) and randomly assigned to one of four treatments: 1) control group (0.0 g kg−1 yeast); 2) yeast (1.50 g kg−1 dry matter intake (DMI) d−1); 3) Se-Cr premix (1.5 mg kg−1 DMI d−1 for each mineral); and 4) yeast-Se-Cr mixture. There were no treatment effects on final BW; whereas lambs fed Se-Cr or yeast-Se-Cr had higher (P0.05) among treatment groups. In conclusion, supplementation with yeast, Se-Cr mixed or yeast-Se-Cr did not improve ADG, final BW, back fat content and carcass yield of growing of Pelibuey×Katahdin lambs. Supplementation with Se-Cr and yeast-Se-Cr increased DMI, and approximately 250 g ADG animal−1 d−1 was produced with no negative effects on growth and health of the animals.