1. Tetrameric and polymeric silver complexes of the omeprazole scaffold; synthesis, structure, in vitro and in vivo antimicrobial activities and DNA interaction.
- Author
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Jakobsen V, Viganor L, Blanco-Fernández A, Howe O, Devereux M, McKenzie CJ, and McKee V
- Subjects
- Microbial Sensitivity Tests, Anti-Bacterial Agents chemical synthesis, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents pharmacology, Antifungal Agents chemical synthesis, Antifungal Agents chemistry, Antifungal Agents pharmacology, Bacteria growth & development, Candida albicans growth & development, Coordination Complexes chemical synthesis, Coordination Complexes chemistry, Coordination Complexes pharmacology, Omeprazole chemistry, Omeprazole pharmacology, Silver chemistry, Silver pharmacology
- Abstract
Two complexes [AgI(pmtbH)]
4 (1) and {[Ag4 (pmtbH)4 (NO3 )4 ·2X}n (2) (where pmtbH is 2-[(2-pyridinylmethyl)thio]-1H-benzimidazole and X is H2 O or MeOH) were synthesised and structurally characterised. Complex 2 showed therapeutic potential against Candida albicans, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa but complex 1 did not show significant activity in vitro. Further in vivo studies using larvae of the insect Galleria mellonella indicated that complex 2 significantly stimulates the immune system and that pre-treatment with the complex offers appreciable protection against all three bacteria. Real-time flow cytometry data support the observed antimicrobial profile of complex 2 and suggest the antimicrobial response may be linked to a form of bacterial programmed cell death (PCD). Complex 2 was found to interact with DNA in the bacterial and fungal cells but it did not cleave plasmid DNA isolated from the three bacteria., (Copyright © 2018 Elsevier Inc. All rights reserved.)- Published
- 2018
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